※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase wzc
Protein Synonyms/Alias
 
Gene Name
 wzc
Gene Synonyms/Alias
 b2060, JW2045
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
713 QDYGYYEYEYKSDAK Y LTP [1]
708 RASAYQDYGYYEYEY Y LTP [1]
711 AYQDYGYYEYEYKSD Y LTP [1]
715 YGYYEYEYKSDAKMT Y LTP [1]
710 SAYQDYGYYEYEYKS Y HTP [2]
705 IFRRASAYQDYGYYE Y HTP [2]
569 DCDMRKGYTHELLGT Y LTP [3],UniProt
Reference
 [1]Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process.
 Grangeasse C,Doublet P,Cozzone AJ
 J. Biol. Chem. 2002, Mar, 1;277(9):7127-35. [PMID:11751920]
 [2]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
 [3]Autophosphorylation of the Escherichia coli protein kinase Wzc regulates tyrosine phosphorylation of Ugd, a UDP-glucose dehydrogenase.
 Grangeasse C,Obadia B,Mijakovic I,Deutscher J,Cozzone AJ,Doublet P
 J. Biol. Chem. 2003, Oct, 10;278(41):39323-9. [PMID:12851388]
Functional Description From UniProt
 FUNCTION: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium Phosphorylates udg
Sequence Annotation From UniProt
 TRANSMEM 32 52 Helical; (Potential)
 TRANSMEM 425 445 Helical; (Potential)
 MOD_RES 569 569 Phosphotyrosine; by autocatalysis (Probable)
 MOD_RES 708 708 Phosphotyrosine (Probable)
 MOD_RES 710 710 Phosphotyrosine (Probable)
 MOD_RES 711 711 Phosphotyrosine (Probable)
 MOD_RES 713 713 Phosphotyrosine (Probable)
 MOD_RES 715 715 Phosphotyrosine (Probable)
Key Word From UniProt
 3D-structure; ATP-binding; Cellinnermembrane; Cellmembrane; Completeproteome; Exopolysaccharidesynthesis; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Referenceproteome; Transferase; Transmembrane; Transmembranehelix; Tyrosine-proteinkinase
Protein Sequence
 MTEKVKQHAA PVTGSDEIDI GRLVGTVIEA RWWVIGITTV FALCAVVYTF FATPIYSADA 60
 LVQIEQNSGN SLVQDIGSAL ANKPPASDAE IQLIRSRLVL GKTVDDLDLD IAVSKNTFPI 120
 FGAGWDRLMG RQNETVKVTT FNRPKEMADQ VFTLNVLDNK NYTLSSDGGF SARGQAGQML 180
 KKEGVTLMVE AIHASPGSEF TVTKYSTLGM INQLQNSLTV TENGKDAGVL SLTYTGEDRE 240
 QIRDILNSIA RNYQEQNIER KSAEASKSLA FLAQQLPEVR SRLDVAENKL NAFRQDKDSV 300
 DLPLEAKAVL DSMVNIDAQL NELTFKEAEI SKLYTKVHPA YRTLLEKRQA LEDEKAKLNG 360
 RVTAMPKTQQ EIVRLTRDVE SGQQVYMQLL NKEQELKITE ASTVGDVRIV DPAITQPGVL 420
 KPKKGLIILG AIILGLMLSI VGVLLRSLFN RGIESPQVLE EHGISVYASI PLSEWQKARD 480
 SVKTIKGIKR YKQSQLLAVG NPTDLAIEAI RSLRTSLHFA MMQAQNNVLM MTGVSPSIGK 540
 TFVCANLAAV ISQTNKRVLL IDCDMRKGYT HELLGTNNVN GLSEILIGQG DITTAAKPTS 600
 IAKFDLIPRG QVPPNPSELL MSERFAELVN WASKNYDLVL IDTPPILAVT DAAIVGRHVG 660
 TTLMVARYAV NTLKEVETSL SRFEQNGIPV KGVILNSIFR RASAYQDYGY YEYEYKSDAK 720
  GO:0005887   C:integral component of plasma membrane IDA:EcoCyc
  GO:0016020   C:membrane IDA:EcoCyc
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0016887   F:ATPase activity IDA:EcoCyc
  GO:0030234   F:enzyme regulator activity IEA:InterPro
  GO:0004713   F:protein tyrosine kinase activity IDA:EcoCyc
  GO:0006200   P:ATP catabolic process IDA:GOC
  GO:0045227   P:capsule polysaccharide biosynthetic process IEA:InterPro
  GO:0009242   P:colanic acid biosynthetic process IMP:EcoCyc
  GO:0009103   P:lipopolysaccharide biosynthetic process IEA:InterPro
  GO:0038083   P:peptidyl-tyrosine autophosphorylation IDA:EcoCyc
  GO:0018108   P:peptidyl-tyrosine phosphorylation IDA:EcoCyc
  IPR025669   AAA_dom.
  IPR005702   EPS_synthesis.
  IPR003856   LipoPS_biosynth.
  IPR027417   P-loop_NTPase.
  PF13614   AAA_31.
  PF02706   Wzz.