※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate decarboxylase beta
Protein Synonyms/Alias
 GAD-beta
Gene Name
 gadB
Gene Synonyms/Alias
 Z2215, ECs2098
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
90 NWIDKEEYPQSAAID Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity)
Sequence Annotation From UniProt
 MOD_RES 276 276 N6-(pyridoxal phosphate)lysine (By
 MOD_RES 446 446 N6-acetyllysine (By similarity)
 MOD_RES 453 453 N6-acetyllysine (By similarity)
 MOD_RES 464 464 N6-acetyllysine (By similarity)
Key Word From UniProt
 Acetylation; Completeproteome; Decarboxylase; Lyase; Pyridoxalphosphate
Protein Sequence
 MDKKQVTDLR SELLDSRFGA KSISTIAESK RFPLHEMRDD VAFQIINDEL YLDGNARQNL 60
 ATFCQTWDDE NVHKLMDLSI NKNWIDKEEY PQSAAIDLRC VNMVADLWHA PAPKNGQAVG 120
 TNTIGSSEAC MLGGMAMKWR WRKRMEAAGK PTDKPNLVCG PVQICWHKFA RYWDVELREI 180
 PMRPGQLFMD PKRMIEACDE NTIGVVPTFG VTYTGNYEFP QPLHDALDKF QADTGIDIDM 240
 HIDAASGGFL APFVAPDIVW DFRLPRVKSI SASGHKFGLA PLGCGWVIWR DEEALPQELV 300
 FNVDYLGGQI GTFAINFSRP AGQVIAQYYE FLRLGREGYT KVQNASYQVA AYLADEIAKL 360
 GPYEFICTGR PDEGIPAVCF KLKDGEDPGY TLYDLSERLR LRGWQVPAFT LGGEATDIVV 420
 MRIMCRRGFE MDFAELLLED YKASLKYLSD HPKLQGIAQQ NSFKHT 466
  GO:0004351   F:glutamate decarboxylase activity IEA:UniProtKB-EC
  GO:0030170   F:pyridoxal phosphate binding IEA:InterPro
  GO:0006536   P:glutamate metabolic process IEA:InterPro
  IPR010107   Glutamate_decarboxylase.
  IPR002129   PyrdxlP-dep_de-COase.
  IPR015424   PyrdxlP-dep_Trfase.
  IPR015421   PyrdxlP-dep_Trfase_major_sub1.
  IPR021115   Pyridoxal-P_BS.
  PF00282   Pyridoxal_deC.
  PS00392   DDC_GAD_HDC_YDC.