※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PTS system mannose-specific EIIAB component
Protein Synonyms/Alias
 
Gene Name
 manX
Gene Synonyms/Alias
 gptB, ptsL; OrderedLocusNames=b1817, JW1806
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
10 IAIVIGTHGWAAEQL H LTP [1]
175 RIDDRLIHGQVATRW H LTP [1]
72 LVDTWGGSPFNAASR S HTP [2]
Reference
 [1]Mannose permease of Escherichia coli. Domain structure and function of the phosphorylating subunit.
 Erni B,Zanolari B,Graff P,Kocher HP
 J. Biol. Chem. 1989, Nov, 5;264(31):18733-41. [PMID:2681202]
 [2]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport
Sequence Annotation From UniProt
 MOD_RES 55 55 N6-acetyllysine
 MOD_RES 234 234 N6-acetyllysine
Key Word From UniProt
 3D-structure; Acetylation; Cellinnermembrane; Cellmembrane; Completeproteome; Cytoplasm; Directproteinsequencing; Kinase; Membrane; Phosphotransferasesystem; Referenceproteome; Sugartransport; Transferase; Transport
Protein Sequence
 MTIAIVIGTH GWAAEQLLKT AEMLLGEQEN VGWIDFVPGE NAETLIEKYN AQLAKLDTTK 60
 GVLFLVDTWG GSPFNAASRI VVDKEHYEVI AGVNIPMLVE TLMARDDDPS FDELVALAVE 120
 TGREGVKALK AKPVEKAAPA PAAAAPKAAP TPAKPMGPND YMVIGLARID DRLIHGQVAT 180
 RWTKETNVSR IIVVSDEVAA DTVRKTLLTQ VAPPGVTAHV VDVAKMIRVY NNPKYAGERV 240
 MLLFTNPTDV ERLVEGGVKI TSVNVGGMAF RQGKTQVNNA VSVDEKDIEA FKKLNARGIE 300
 LEVRKVSTDP KLKMMDLISK IDK 323
  GO:0005737   C:cytoplasm IDA:EcoCyc
  GO:0005829   C:cytosol IDA:EcoCyc
  GO:0005887   C:integral component of plasma membrane IDA:EcoCyc
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0016301   F:kinase activity IDA:EcoCyc
  GO:0022870   F:protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity IDA:EcoCyc
  GO:0015761   P:mannose transport IDA:GOC
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IDA:EcoCyc
  IPR013789   PTS_EIIA_man.
  IPR004701   PTS_EIIA_man-typ.
  IPR004720   PTS_IIB_sorbose-sp.
  IPR018455   PTS_IIB_sorbose-sp_subgr.
  PF03610   EIIA-man.
  PF03830   PTSIIB_sorb.
  PS51096   PTS_EIIA_TYPE_4.
  PS51101   PTS_EIIB_TYPE_4.