※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate kinase
Protein Synonyms/Alias
 AK
Gene Name
 adk
Gene Synonyms/Alias
 dnaW, plsA; OrderedLocusNames=b0474, JW0463
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
30 KYGIPQISTGDMLRA S HTP [1]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Sequence Annotation From UniProt
 MOD_RES 192 192 N6-acetyllysine
Key Word From UniProt
 3D-structure; Acetylation; ATP-binding; Completeproteome; Cytoplasm; Directproteinsequencing; Kinase; Nucleotidebiosynthesis; Nucleotide-binding; Referenceproteome; Transferase
Protein Sequence
 MRIILLGAPG AGKGTQAQFI MEKYGIPQIS TGDMLRAAVK SGSELGKQAK DIMDAGKLVT 60
 DELVIALVKE RIAQEDCRNG FLLDGFPRTI PQADAMKEAG INVDYVLEFD VPDELIVDRI 120
 VGRRVHAPSG RVYHVKFNPP KVEGKDDVTG EELTTRKDDQ EETVRKRLVE YHQMTAPLIG 180
 YYSKEAEAGN TKYAKVDGTK PVAEVRADLE KILG 214
  GO:0005829   C:cytosol IDA:EcoCyc
  GO:0004017   F:adenylate kinase activity IDA:EcoCyc
  GO:0016208   F:AMP binding IDA:EcoCyc
  GO:0005524   F:ATP binding IDA:EcoCyc
  GO:0000287   F:magnesium ion binding IDA:EcoCyc
  GO:0006172   P:ADP biosynthetic process IMP:EcoliWiki
  GO:0044209   P:AMP salvage IEA:UniProtKB-UniPathway
  GO:0046939   P:nucleotide phosphorylation IDA:GOC
  GO:0008654   P:phospholipid biosynthetic process IMP:EcoliWiki
  GO:0015951   P:purine ribonucleotide interconversion IMP:EcoCyc
  GO:0032774   P:RNA biosynthetic process IMP:EcoliWiki
  GO:0006412   P:translation IMP:EcoliWiki
  IPR006259   Adenyl_kin_sub.
  IPR000850   Adenylat/UMP-CMP_kin.
  IPR007862   Adenylate_kinase_lid-dom.
  IPR027417   P-loop_NTPase.
  PF05191   ADK_lid.
  PS00113   ADENYLATE_KINASE.
  PR00094   ADENYLTKNASE.