※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ECF RNA polymerase sigma factor SigH
Protein Synonyms/Alias
 ECF sigma factor SigH;  Sigma-H factor
Gene Name
 sigH
Gene Synonyms/Alias
 rpoE; OrderedLocusNames=Mb3250c
Created Date
 3-June-2014
Organism
 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
NCBI Taxa ID
 233413
Phosphorylation
Position
Peptide
Code
Type
References
110 EYPTEQITDWQLASN T LTP [1]
106 RQPAEYPTEQITDWQ T LTP [1]
Reference
 [1]Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.
 Park ST,Kang CM,Husson RN
 Proc. Natl. Acad. Sci. U.S.A. 2008, Sep, 2;105(35):13105-10. [PMID:18728196]
Functional Description From UniProt
 FUNCTION: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress response; it is believed to control protein processing in the extracytoplasmic compartment (By similarity)
Sequence Annotation From UniProt
 MOD_RES 106 106 Phosphothreonine (Probable)
 MOD_RES 110 110 Phosphothreonine (Probable)
Key Word From UniProt
 Completeproteome; DNA-binding; Phosphoprotein; Sigmafactor; Stressresponse; Transcription; Transcriptionregulation
Protein Sequence
 MADIDGVTGS AGLQPGPSEE TDEELTARFE RDAIPLLDQL YGGALRMTRN PADAEDLLQE 60
 TMVKAYAGFR SFRHGTNLKA WLYRILTNTY INSYRKKQRQ PAEYPTEQIT DWQLASNAEH 120
 SSTGLRSAEV EALEALPDTE IKEALQALPE EFRMAVYYAD VEGFPYKEIA EIMDTPIGTV 180
 MSRLHRGRRQ LRGLLADVAR DRGFARGEQA HEGVSS 216
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0016987   F:sigma factor activity IEA:UniProtKB-KW
  GO:0006352   P:DNA-templated transcription, initiation IEA:InterPro
  GO:0006950   P:response to stress IEA:UniProtKB-KW
  IPR014284   RNA_pol_sigma-70_dom.
  IPR014293   RNA_pol_sigma70_actinobac.
  IPR000838   RNA_pol_sigma70_ECF_CS.
  IPR007627   RNA_pol_sigma70_r2.
  IPR013249   RNA_pol_sigma70_r4_t2.
  IPR013325   RNA_pol_sigma_r2.
  IPR013324   RNA_pol_sigma_r3_r4.
  IPR011991   WHTH_DNA-bd_dom.
  PF04542   Sigma70_r2.
  PF08281   Sigma70_r4_2.
  PS01063   SIGMA70_ECF.