※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-ribosylhomocysteine lyase
Protein Synonyms/Alias
 
Gene Name
 luxS
Gene Synonyms/Alias
 SA1936
Created Date
 3-June-2014
Organism
 Staphylococcus aureus (strain N315)
NCBI Taxa ID
 158879
Phosphorylation
Position
Peptide
Code
Type
References
14 ESFNLDHTKVVAPFI T LTP [1]
Reference
 [1]The Staphylococcus aureus autoinducer-2 synthase LuxS is regulated by Ser/Thr phosphorylation.
 Cluzel ME,Zanella-Cléon I,Cozzone AJ,Fütterer K,Duclos B,Molle V
 J. Bacteriol. 2010, Dec;192(23):6295-301. [PMID:20870760]
Functional Description From UniProt
 FUNCTION: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Autoinducersynthesis; Completeproteome; Iron; Lyase; Metal-binding; Quorumsensing
Protein Sequence
 MTKMNVESFN LDHTKVVAPF IRLAGTMEGL NGDVIHKYDI RFKQPNKEHM DMPGLHSLEH 60
 LMAENIRNHS DKVVDLSPMG CQTGFYVSFI NHDNYDDVLN IVEATLNDVL NATEVPACNE 120
 VQCGWAASHS LEGAKTIAQA FLDKRNEWHD VFGTGK 156
  GO:0005506   F:iron ion binding IEA:InterPro
  GO:0043768   F:S-ribosylhomocysteine lyase activity IEA:UniProtKB-HAMAP
  GO:0009372   P:quorum sensing IEA:UniProtKB-HAMAP
  IPR011249   Metalloenz_LuxS/M16.
  IPR003815   S-ribosylhomocysteinase.
  PF02664   LuxS.
  PR01487   LUXSPROTEIN.