UniProt Accession

 NFUA_ECOLI;  P63020;  P46847;  Q2M779

Genbank Protein ID

 U18997;  U00096;  AP009048

Genbank Nucleotide ID

 AAA58212.1;  AAC76439.1;  BAE77877.1

Protein Name

 Fe/S biogenesis protein NfuA

Protein Synonyms/Alias

 

Gene Name

 nfuA

Gene Synonyms/Alias

 gntY, yhgI; OrderedLocusNames=b3414, JW3377

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Involved in iron-sulfur cluster biogenesis under severe conditions such as iron starvation or oxidative stress. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. Required for E.coli to sustain oxidative stress and iron starvation. Also necessary for the use of extracellular DNA as the sole source of carbon and energy

Sequence Annotation From UniProt

 

Key Word From UniProt

 4Fe-4S; Completeproteome; Iron; Iron-sulfur; Metal-binding; Referenceproteome; Stressresponse

Protein Sequence

  GO:0051539   F:4 iron, 4 sulfur cluster binding IDA:EcoCyc
  GO:0005506   F:iron ion binding IEA:InterPro
  GO:0015976   P:carbon utilization IMP:EcoCyc
  GO:0010106   P:cellular response to iron ion starvation IMP:EcoCyc
  GO:0016226   P:iron-sulfur cluster assembly IDA:EcoliWiki
  GO:0097428   P:protein maturation by iron-sulfur cluster transfer IDA:EcoCyc
  GO:0006979   P:response to oxidative stress IMP:EcoCyc

  IPR017726   Fe/S_biogenesis_protein_NfuA.
  IPR000361   FeS_biogenesis.
  IPR001075   NIF_FeS_clus_asmbl_NifU_C.

  PF01521   Fe-S_biosyn.
  PF01106   NifU.