※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Protein Synonyms/Alias
 
Gene Name
 ispG
Gene Synonyms/Alias
 gcpE; OrderedLocusNames=Z3778, ECs3377
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
330 GNKKSGLYEDGVRKD Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 4Fe-4S; Completeproteome; Iron; Iron-sulfur; Isoprenebiosynthesis; Metal-binding; Oxidoreductase
Protein Sequence
 MHNQAPIQRR KSTRIYVGNV PIGDGAPIAV QSMTNTRTTD VEATVNQIKA LERVGADIVR 60
 VSVPTMDAAE AFKLIKQQVN VPLVADIHFD YRIALKVAEY GVDCLRINPG NIGNEERIRM 120
 VVDCARDKNI PIRIGVNAGS LEKDLQEKYG EPTPQALLES AMRHVDHLDR LNFDQFKVSV 180
 KASDVFLAVE SYRLLAKQID QPLHLGITEA GGARSGAVKS AIGLGLLLSE GIGDTLRVSL 240
 AADPVEEIKV GFDILKSLRI RSRGINFIAC PTCSRQEFDV IGTVNALEQR LEDIITPMDV 300
 SIIGCVVNGP GEALVSTLGV TGGNKKSGLY EDGVRKDRLD NNDMIDQLEA RIRAKASQLD 360
 EARRIDVQQV EK 372
  GO:0051539   F:4 iron, 4 sulfur cluster binding IEA:UniProtKB-HAMAP
  GO:0046429   F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity IEA:UniProtKB-HAMAP
  GO:0005506   F:iron ion binding IEA:InterPro
  GO:0019288   P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA:UniProtKB-UniPathway
  GO:0016114   P:terpenoid biosynthetic process IEA:UniProtKB-HAMAP
  IPR013785   Aldolase_TIM.
  IPR011005   Dihydropteroate_synth-like.
  IPR016425   IspG_bac.
  IPR004588   IspG_bac-typ.
  PF04551   GcpE.