UniProt Accession

 MDH_ECOLI;  P61889;  O30401;  O30402;  O30403;  P06994;  Q2M8X7;  Q59343;  Q59344;  Q59345;  Q59346;  Q59347;  Q59348;  Q60133;  Q60150;  Q933J3;  Q93R02;  Q9FDQ3;  Q9FDQ4;  Q9FDQ5

Genbank Protein ID

 Y00129;  M24777;  U18997;  U00096;  AP009048;  M10417;  U04742;  U04743;  U04744;  U04745;  U04746;  U04747;  U04748;  U04749;  U04750;  U04751;  U04752;  U04753;  U04754;  U04755;  U04756;  U04757;  U04758;  U04759;  U04760;  U04770;  AF004170;  AF004171;  AF004172;  AF004173;  AF004174;  AF004175;  AF004176;  AF004177;  AF004179;  AF004180;  AF004182;  AF004183;  AF004184;  AF004186;  AF004187;  AF004188;  AF004190;  AF004191;  AF004195;  AF004196;  AF004199;  AF004200;  AF004201;  AF004202;  AF004203;  AF004204;  AF004205;  AF004206;  AF004207;  AF004208;  AF004209;  AF091758;  AF091759;  AF091760;  AF091761;  AF091762;  AF091763;  AF091764;  AF091765;  AF091766;  AF091767;  AF091768;  AF091769;  AF091770;  AF091771;  AF091772;  AF091773;  AF091774;  AF091775;  AF091776;  AF091777;  AF091778

Genbank Nucleotide ID

 CAA68326.1;  AAA16107.1;  AAA58038.1;  AAC76268.1;  BAE77279.1;  AAA24147.1;  AAC43730.1;  AAC43731.1;  AAC43732.1;  AAC43733.1;  AAC43734.1;  AAC43735.1;  AAC43736.1;  AAC43737.1;  AAC43738.1;  AAC43739.1;  AAC43740.1;  AAC43741.1;  AAC43742.1;  AAC43743.1;  AAC43744.1;  AAC43745.1;  AAC43746.1;  AAC43747.1;  AAC43748.1;  AAC43758.1;  AAB87003.1;  AAB87004.1;  AAB87005.1;  AAB87006.1;  AAB87007.1;  AAB87008.1;  AAB87009.1;  AAB87010.1;  AAB87012.1;  AAB87013.1;  AAB87015.1;  AAB87016.1;  AAB87017.1;  AAB87019.1;  AAB87020.1;  AAB87021.1;  AAB87023.1;  AAB87024.1;  AAB87028.1;  AAB87029.1;  AAB87032.1;  AAB87033.1;  AAB87034.1;  AAB87035.1;  AAB87036.1;  AAB87037.1;  AAB87038.1;  AAB87039.1;  AAB87040.1;  AAB87041.1;  AAB87042.1;  AAF97988.1;  AAF97989.1;  AAF97990.1;  AAF97991.1;  AAF97992.1;  AAF97993.1;  AAF97994.1;  AAF97995.1;  AAF97996.1;  AAF97997.1;  AAF97998.1;  AAF97999.1;  AAF98000.1;  AAF98001.1;  AAF98002.1;  AAF98003.1;  AAF98004.1;  AAF98005.1;  AAF98006.1;  AAF98007.1;  AAF98008.1

Protein Name

 Malate dehydrogenase

Protein Synonyms/Alias

 

Gene Name

 mdh

Gene Synonyms/Alias

 b3236, JW3205

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]

Functional Description From UniProt

 FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Completeproteome; Directproteinsequencing; NAD; Oxidoreductase; Referenceproteome; Tricarboxylicacidcycle

Protein Sequence

  GO:0005737   C:cytoplasm IDA:EcoliWiki
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0019898   C:extrinsic component of membrane IDA:EcoliWiki
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0030060   F:L-malate dehydrogenase activity IEA:UniProtKB-HAMAP
  GO:0016615   F:malate dehydrogenase activity IDA:EcoliWiki
  GO:0016491   F:oxidoreductase activity IDA:EcoliWiki
  GO:0009061   P:anaerobic respiration IDA:EcoliWiki
  GO:0044262   P:cellular carbohydrate metabolic process IEA:InterPro
  GO:0006113   P:fermentation IDA:EcoliWiki
  GO:0006096   P:glycolytic process IDA:EcoliWiki
  GO:0006108   P:malate metabolic process IDA:EcoliWiki
  GO:0006099   P:tricarboxylic acid cycle IDA:EcoliWiki

  IPR001557   L-lactate/malate_DH.
  IPR022383   Lactate/malate_DH_C.
  IPR001236   Lactate/malate_DH_N.
  IPR015955   Lactate_DH/Glyco_Ohase_4_C.
  IPR001252   Malate_DH_AS.
  IPR010097   Malate_DH_type1.
  IPR023958   Malate_DH_type1_bac.
  IPR016040   NAD(P)-bd_dom.

  PF02866   Ldh_1_C.
  PF00056   Ldh_1_N.

  PS00068   MDH.