| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable glutamate/gamma-aminobutyrate antiporter |
Protein Synonyms/Alias | |
Gene Name | gadC |
Gene Synonyms/Alias | acsA, xasA; OrderedLocusNames=Z2216, ECs2097 |
Created Date | 3-June-2014 |
Organism | Escherichia coli O157:H7 |
NCBI Taxa ID | 83334 |
Phosphorylation | Position | Peptide | Code | Type | References | | 503 | PRARSPHYIVMNDKK | Y | HTP | [1] | |
Reference | [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A PLoS Pathog. 2013;9(6):e1003403. [ PMID:23785281] |
Functional Description From UniProt | FUNCTION: Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity) |
| TRANSMEM 15 35 Helical; (Potential)
TRANSMEM 42 62 Helical; (Potential)
TRANSMEM 94 114 Helical; (Potential)
TRANSMEM 128 148 Helical; (Potential)
TRANSMEM 158 178 Helical; (Potential)
TRANSMEM 201 221 Helical; (Potential)
TRANSMEM 240 260 Helical; (Potential)
TRANSMEM 292 312 Helical; (Potential)
TRANSMEM 336 356 Helical; (Potential)
TRANSMEM 367 387 Helical; (Potential)
TRANSMEM 413 433 Helical; (Potential)
TRANSMEM 446 466 Helical; (Potential) |
| Amino-acidtransport; Antiport; Cellinnermembrane; Cellmembrane; Completeproteome; Membrane; Transmembrane; Transmembranehelix; Transport; Virulence |
Protein Sequence | MATLVQTGKA KQLTLLGFFA ITASMVMAVY EYPTFATSGF SLVFFLLLGG ILWFIPVGLC 60
AAEMATVDGW EEGGVFAWVS NTLGPRWGFA AISFGYLQIA IGFIPMLYFV LGALSYILKW 120
PALNEDPITK TIAALIILWA LALTQFGGTK YTARIAKVGF FAGILLPAFI LIALAAIYLH 180
SGAPVAIEMD SKTFFPDFSK VGTLVVFVAF ILSYMGVEAS ATHVNEMSNP GRDYPLAMLL 240
LMVAAICLSS VGGLSIAMVI PGNEINLSAG VMQTFTVLMS HVAPEIEWTV RVISALLLLG 300
VLAEIASWIV GPSRGMYVTA QKNLLPAAFA KMNKNGVPVT LVISQLVITS IALIILTNTG 360
GGNNMSFLIA LALTVVIYLC AYFMLFIGYI VLVLKHPDLK RTFNIPGGKG VKLVVAIVGL 420
LTSIMAFIVS FLPPDNIQGD STDMYVELLV VSFLVVLALP FILYAVHDRK GKANTGVTLE 480
PINSQNAPKG HFFLHPRARS PHYIVMNDKK H 511 |
| GO:0016021 C:integral component of membrane IEA:UniProtKB-KW GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell GO:0015171 F:amino acid transmembrane transporter activity IEA:InterPro GO:0015297 F:antiporter activity IEA:UniProtKB-KW GO:0009405 P:pathogenesis IEA:UniProtKB-KW |
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