| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolating cytotoxin autotransporter |
Protein Synonyms/Alias | |
Gene Name | vacA |
Gene Synonyms/Alias | HP_0887 |
Created Date | 3-June-2014 |
Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
NCBI Taxa ID | 85962 |
Phosphorylation | Position | Peptide | Code | Type | References | | 1245 | AAHNPLSTHARVMMG | T | HTP | [1] | | 1244 | NAAHNPLSTHARVMM | S | HTP | [1] | |
Reference | [1]Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins. Ge R,Sun X,Xiao C,Yin X,Shan W,Chen Z,He QY Proteomics 2011, Apr;11(8):1449-61. [ PMID:21360674] |
Functional Description From UniProt | FUNCTION: Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions |
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| Celloutermembrane; Completeproteome; Membrane; Periplasm; Referenceproteome; Secreted; Signal; Toxin; Transmembrane; Transmembranebetastrand |
Protein Sequence | MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT GAAVGTVSGL 60
LGWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL YRSLLSSKID GGWDWGNAAT 120
HYWVKGGQWN KLEVDMKDAV GTYNLSGLRN FTGGDLDVNM QKATLRLGQF NGNSFTSYKD 180
SADRTTRVDF NAKNILIDNF LEINNRVGSG AGRKASSTVL TLQASEGITS SKNAEISLYD 240
GATLNLASNS VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDHNAAQA 300
GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPKDKPS NTTQNNANNN QQNSAQNNSN 360
TQVINPPNSA QKTEIQPTQV IDGPFAGGKD TVVNIDRINT NADGTIKVGG YKASLTTNAA 420
HLHIGKGGIN LSNQASGRTL LVENLTGNIT VDGPLRVNNQ VGGYALAGSS ANFEFKAGTD 480
TKNGTATFNN DISLGRFVNL KVDAHTANFK GIDTGNGGFN TLDFSGVTGK VNINKLITAS 540
TNVAVKNFNI NELVVKTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI FSGGVKFKSG 600
EKLVIDEFYY SPWNYFDARN IKNVEITRKF ASSTPENPWG TSKLMFNNLT LGQNAVMDYS 660
QFSNLTIQGD FINNQGTINY LVRGGQVATL NVGNAAAMFF SNNVDSATGF YQPLMKINSA 720
QDLIKNKEHV LLKAKIIGYG NVSLGTNSIS NVNLIEQFKE RLALYNNNNR MDICVVRNTD 780
DIKACGTAIG NQSMVNNPDN YKYLIGKAWK NIGISKTANG SKISVYYLGN STPTEKGGNT 840
TNLPTNTTSN VRSANNALAQ NAPFAQPSAT PNLVAINQHD FGTIESVFEL ANRSKDIDTL 900
YANSGAQGRD LLQTLLIDSH DAGYARQMID NTSTGEITKQ LNAATTTLNN IASLEHKTSS 960
LQTLSLSNAM ILNSRLVNLS RRHTNNIDSF AQRLQALKDQ KFASLESAAE VLYQFAPKYE 1020
KPTNVWANAI GGTSLNNGGN ASLYGTSAGV DAYLNGEVEA IVGGFGSYGY SSFNNQANSL 1080
NSGANNTNFG VYSRIFANQH EFDFEAQGAL GSDQSSLNFK SALLRDLNQS YNYLAYSAAT 1140
RASYGYDFAF FRNALVLKPS VGVSYNHLGS TNFKSNSNQV ALKNGSSSQH LFNASANVEA 1200
RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAH NPLSTHARVM MGGELKLAKE 1260
VFLNLGFVYL HNLISNIGHF ASNLGMRYSF 1290 |
| GO:0009279 C:cell outer membrane IEA:UniProtKB-SubCell GO:0009986 C:cell surface IEA:UniProtKB-SubCell GO:0005576 C:extracellular region IEA:UniProtKB-SubCell GO:0016021 C:integral component of membrane IEA:UniProtKB-KW GO:0042597 C:periplasmic space IEA:UniProtKB-SubCell GO:0009405 P:pathogenesis IEA:InterPro |
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