※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase AfsK
Protein Synonyms/Alias
 
Gene Name
 afsK
Gene Synonyms/Alias
 SCO4423; ORFNames=SC6F11.21, SCD6.01
Created Date
 3-June-2014
Organism
 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
NCBI Taxa ID
 100226
Phosphorylation
Position
Peptide
Code
Type
References
71 VEAARAVSGFYTAAV S LTP [1],UniProt
128 GVAEALQSIHGAGLV S LTP [1]
168 GVSNTRLTMTNVAVG T LTP [1],UniProt
Reference
 [1]Self-activation of serine/threonine kinase AfsK on autophosphorylation at threonine-168.
 Tomono A,Mashiko M,Shimazu T,Inoue H,Nagasawa H,Yoshida M,Ohnishi Y,Horinouchi S
 J. Antibiot. 2006, Feb;59(2):117-23. [PMID:16629414]
Functional Description From UniProt
 FUNCTION: Involved in the regulation of secondary metabolism by phosphorylating, on both Ser and Thr, the AfsR global regulatory protein involved in the control of secondary metabolism
Sequence Annotation From UniProt
 MOD_RES 71 71 Phosphoserine; by autocatalysis
 MOD_RES 168 168 Phosphothreonine; by autocatalysis
Key Word From UniProt
 ATP-binding; Completeproteome; Kinase; Nucleotide-binding; Phosphoprotein; Referenceproteome; Serine/threonine-proteinkinase; Transferase
Protein Sequence
 MVDQLTQHDP RRIGPFEVLG RLGAGGMGLV YLARSASGRR VAIKTVRTEL AEDQLFRVRF 60
 TREVEAARAV SGFYTAAVVD ADPRAAVPWL ATAYVPAPSL EEIVNECGPM PAQAVRWLAA 120
 GVAEALQSIH GAGLVHRDLK PSNVLVVEDG PRVIDFGIAS GVSNTRLTMT NVAVGTPAYM 180
 SPEQAKDSRS VTGASDVFSL GSMLVFAATG HPPFHGANPV ETVFMLLREG PDLEGLPDEL 240
 RPLIESCMQM EATGRPNPAD LQAQLAPHLF GSGSDDSGTA SAWLPERAVG LIEGRRNGRP 300
 AVKPATTAGG RGHGHGPSGA RAPVHAPPLP PPPAHDPVVP APPAHVPAVP APVGAPDGGP 360
 VRLPGAAVPI GPGPRVADMR AAAVAAPPPE SALAASWSRP RPGVNGADPA VPAPAPAPPE 420
 ASPAGWRPWR FRMSNDVWGT PRVAEDLVYV TSFEVHALDV ATGRRRFKTR DVAWSMAVAD 480
 GRIHASDGPT LFALDAREGA DLWRVQTDAW VYSLQADRGT VLTATRGGGV QAWEASAGQK 540
 LWEVTGAQTD FESPEAGAAL HDGTAYVWQD ARLRALDART GDERWSYPIG DAASCGGVPV 600
 RLTQAPDGYV YVAAGTRVLA LEVASGHVRW HFEAPAVFLA PPTFVPGPAV TGGGVYLADY 660
 LGTVYALDAT DGRDRWRIAT EARSSTDPVL VAAGHVHVGS GKGLYTLDAV TGTPKWRFQA 720
 GGDIVGAPAV AEGRIHFGSS DHLLYTLKAD DGRLRWKLAT GGEITGSPVV RDGIVYACSK 780
 DRCVYALDAE KGTGTARTT 799
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  IPR011009   Kinase-like_dom.
  IPR018391   PQQ_beta_propeller_repeat.
  IPR002372   PQQ_repeat.
  IPR000719   Prot_kinase_dom.
  IPR017441   Protein_kinase_ATP_BS.
  IPR027295   Quinonprotein_ADH-like_fam.
  IPR011047   Quinonprotein_ADH-like_supfam.
  IPR008271   Ser/Thr_kinase_AS.
  PF00069   Pkinase.
  PF01011   PQQ.
  SM00564   PQQ.
  PS00107   PROTEIN_KINASE_ATP.
  PS50011   PROTEIN_KINASE_DOM.
  PS00108   PROTEIN_KINASE_ST.