Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Stage 0 sporulation protein A |
Protein Synonyms/Alias | |
Gene Name | spo0A |
Gene Synonyms/Alias | |
Created Date | 3-June-2014 |
Organism | Geobacillus stearothermophilus (Bacillus stearothermophilus) |
NCBI Taxa ID | 1422 |
Phosphorylation | Position | Peptide | Code | Type | References | 55 | RPDILLLDIIMPHLD | D | LTP | [1],UniProt | |
Reference | [1]Phosphorylated aspartate in the structure of a response regulator protein. Lewis RJ,Brannigan JA,Muchová K,Barák I,Wilkinson AJ J. Mol. Biol. 1999, Nov, 19;294(1):9-15. [ PMID:10556024] |
Functional Description From UniProt | FUNCTION: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity) |
| MOD_RES 55 55 4-aspartylphosphate |
| 3D-structure; Activator; Calcium; Cytoplasm; DNA-binding; Metal-binding; Phosphoprotein; Repressor; Sporulation; Transcription; Transcriptionregulation; Two-componentregulatorysystem |
Protein Sequence | MSIKVCIADD NRELVSLLDE YISSQPDMEV IGTAYNGQDC LQMLEEKRPD ILLLDIIMPH 60 LDGLAVLERI RAGFEHQPNV IMLTAFGQED VTKKAVELGA SYFILKPFDM ENLAHHIRQV 120 YGKTTPVVRK AAPAPQVRDN KPKNLDASIT SIIHEIGVPA HIKGYLYLRE AIAMVYHDIE 180 LLGSITKVLY PDIAKKYNTT ASRVERAIRH AIEVAWSRGN LESISSLFGY TVSVSKAKPT 240 NSEFIAMVAD KLRLEHKAS 259 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0005509 F:calcium ion binding IEA:InterPro GO:0003677 F:DNA binding IEA:UniProtKB-KW GO:0000156 F:phosphorelay response regulator activity IEA:InterPro GO:0003700 F:sequence-specific DNA binding transcription factor activity IEA:InterPro GO:0051606 P:detection of stimulus IEA:InterPro GO:0042173 P:regulation of sporulation resulting in formation of a cellular spore IEA:InterPro GO:0030435 P:sporulation resulting in formation of a cellular spore IEA:UniProtKB-KW GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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