※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Stage 0 sporulation protein A
Protein Synonyms/Alias
 
Gene Name
 spo0A
Gene Synonyms/Alias
 
Created Date
 3-June-2014
Organism
 Geobacillus stearothermophilus (Bacillus stearothermophilus)
NCBI Taxa ID
 1422
Phosphorylation
Position
Peptide
Code
Type
References
55 RPDILLLDIIMPHLD D LTP [1],UniProt
Reference
 [1]Phosphorylated aspartate in the structure of a response regulator protein.
 Lewis RJ,Brannigan JA,Muchová K,Barák I,Wilkinson AJ
 J. Mol. Biol. 1999, Nov, 19;294(1):9-15. [PMID:10556024]
Functional Description From UniProt
 FUNCTION: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity)
Sequence Annotation From UniProt
 MOD_RES 55 55 4-aspartylphosphate
Key Word From UniProt
 3D-structure; Activator; Calcium; Cytoplasm; DNA-binding; Metal-binding; Phosphoprotein; Repressor; Sporulation; Transcription; Transcriptionregulation; Two-componentregulatorysystem
Protein Sequence
 MSIKVCIADD NRELVSLLDE YISSQPDMEV IGTAYNGQDC LQMLEEKRPD ILLLDIIMPH 60
 LDGLAVLERI RAGFEHQPNV IMLTAFGQED VTKKAVELGA SYFILKPFDM ENLAHHIRQV 120
 YGKTTPVVRK AAPAPQVRDN KPKNLDASIT SIIHEIGVPA HIKGYLYLRE AIAMVYHDIE 180
 LLGSITKVLY PDIAKKYNTT ASRVERAIRH AIEVAWSRGN LESISSLFGY TVSVSKAKPT 240
 NSEFIAMVAD KLRLEHKAS 259
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005509   F:calcium ion binding IEA:InterPro
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0051606   P:detection of stimulus IEA:InterPro
  GO:0042173   P:regulation of sporulation resulting in formation of a cellular spore IEA:InterPro
  GO:0030435   P:sporulation resulting in formation of a cellular spore IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR011006   CheY-like_superfamily.
  IPR016032   Sig_transdc_resp-reg_C-effctor.
  IPR001789   Sig_transdc_resp-reg_receiver.
  IPR014879   Spo0A_C.
  IPR012052   Spore_0_A.
  IPR011991   WHTH_DNA-bd_dom.
  PF00072   Response_reg.
  PF08769   Spo0A_C.
  SM00448   REC.
  PS50110   RESPONSE_REGULATORY.