※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA translocase FtsK
Protein Synonyms/Alias
 
Gene Name
 ftsK
Gene Synonyms/Alias
 b0890, JW0873
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
5 ***MSQEYIEDKEVT Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum
Sequence Annotation From UniProt
 TRANSMEM 22 42 Helical; (Potential)
 TRANSMEM 76 96 Helical; (Potential)
 TRANSMEM 112 132 Helical; (Potential)
 TRANSMEM 137 157 Helical; (Potential)
 TRANSMEM 164 184 Helical; (Potential)
Key Word From UniProt
 3D-structure; ATP-binding; Cellcycle; Celldivision; Cellinnermembrane; Cellmembrane; Chromosomepartition; Completeproteome; DNA-binding; Membrane; Nucleotide-binding; Referenceproteome; Transmembrane; Transmembranehelix
Protein Sequence
 MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI 60
 HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL 120
 ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG 180
 WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL 240
 RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT 300
 QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW 360
 QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY 420
 YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE 480
 PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP 540
 PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR 600
 VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ 660
 QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK 720
 ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ 780
 PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL 840
 PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG 900
 VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN 960
 PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI 1020
 MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE 1080
 KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR 1140
 LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG 1200
 MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD 1260
 GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR 1320
 EVLAPPPFD 1329
  GO:0005887   C:integral component of plasma membrane IDA:EcoCyc
  GO:0016020   C:membrane IDA:EcoliWiki
  GO:0005886   C:plasma membrane EXP:EcoliWiki
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0016887   F:ATPase activity IDA:CACAO
  GO:0003677   F:DNA binding IDA:EcoliWiki
  GO:0015616   F:DNA translocase activity IDA:EcoCyc
  GO:0033676   F:double-stranded DNA-dependent ATPase activity IMP:CACAO
  GO:0042802   F:identical protein binding IDA:EcoCyc
  GO:0043565   F:sequence-specific DNA binding IDA:EcoCyc
  GO:0006200   P:ATP catabolic process IDA:GOC
  GO:0051301   P:cell division IMP:CACAO
  GO:0071236   P:cellular response to antibiotic IMP:EcoliWiki
  GO:0007059   P:chromosome segregation IDA:EcoliWiki
  GO:0000920   P:cytokinetic cell separation IMP:EcoliWiki
  GO:0043085   P:positive regulation of catalytic activity IDA:EcoCyc
  GO:0045893   P:positive regulation of transcription, DNA-templated IMP:EcoliWiki
  GO:0006970   P:response to osmotic stress IMP:EcoliWiki
  GO:0009651   P:response to salt stress IMP:EcoliWiki
  IPR002543   Cell_div_FtsK/SpoIIIE.
  IPR018541   DNA_translocase_Ftsk_gamma.
  IPR025199   DUF4117.
  IPR027417   P-loop_NTPase.
  PF13491   DUF4117.
  PF09397   Ftsk_gamma.
  PF01580   FtsK_SpoIIIE.
  SM00843   Ftsk_gamma.
  PS50901   FTSK.