※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isoleucine--tRNA ligase
Protein Synonyms/Alias
 IleRS
Gene Name
 ileS
Gene Synonyms/Alias
 Saci_0599
Created Date
 3-June-2014
Organism
 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
NCBI Taxa ID
 330779
Phosphorylation
Position
Peptide
Code
Type
References
24 YWDDNNIYKKLKEIN Y HTP [1]
1050 SKADVSVSMTSKFDP S HTP [1]
375 SASEEIISDLKQRSA S HTP [1]
Reference
 [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius.
 Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV
 Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [PMID:24078887]
Functional Description From UniProt
 FUNCTION: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; Zinc
Protein Sequence
 MTSKFDPLKF EEEVLKYWDD NNIYKKLKEI NEKNHKKFLF IDGPPYPSSP IPHIGTVWNK 60
 TIKDCILRYE RLMGYSVKDQ PGYDTHGLPI EVETEKRLGI KSKAEIIEKV GVDNFISKCK 120
 EFAVNNSKSL TQNFRNLGIF MDWENPYFTF NNDYISNSWA VIKKAYERGL LYKGVHVLHW 180
 CSRCETTLAD YEVSEYRDLE DPSIYVKFRV KGEPNRYLVI WTTTPWTLPA NVFVMINKDF 240
 EYADVRVGDE ILVIAKDRVK ELMKEARIKE YKILRVYKGE ELLGLEYEHP LADIVSAQSK 300
 INNHHKVLDG GEAVTLQEGT GLVHSAPGHG DVDFEIGKKY DMPVVMLVND KGEFTQDSGK 360
 YAGKYVRSAS EEIISDLKQR SALLHASKIV HRYPVCWRCK TPLILRAIEQ WFIAVSKLKD 420
 HLMGEIDRVR WIPDWGKTRI GNMVKEVRDW VISRQRFWGT PLPIWVCSNC QNIIVVGGVD 480
 ELSKISINQV PQDLHRPWID SVVVRCEKCG GEARRISDVA DVWFDSGVAF FASLGQDWRK 540
 RWSELGPVDL VLEGHDQLRG WFFSLLRTGV ILMDKAPYEA VLVHGFMLDE QGREMHKSSG 600
 NYVEPSQVVS KYGRDTLRLW LLRNTTWEDA KFSWKSLDMT RRDLNIIWNV YVFANTYMSL 660
 DEFKYSKYSY NDIKDYLKLE DIWLLSRYYR MLKEVIEAMK EYKVHELANK VTAFIIDDIS 720
 RFYLRVTRKR AWNEANDPDK IAMYYVLYHV LKGSLILLST VIPFTAEKIY LDFVQERLES 780
 ISMEKIPEIK EEFINSEIEE AFEVAKEIID AGLNARAKAG IKLRWPLKEV YVFLVSDKDR 840
 RSIEKITDVL SSLLNSKSII IEGIDGYKRF SKIRATPNTG SIGPTFKRLS VKVAEYIQNN 900
 SDKVAQDIVS KGYHEFNVDS ENLRLDISHV NLVEEVEKGY VSARFSKGVV LLKQEMSKEE 960
 EEEGIIRDLI RRIQFMRKQL SLNVNEYILL SIRAPDDKVD LIKKWEQYIK NETRAKELRI 1020
 GDVSGDLIQD WDVEEETYTI GVSKADVSVS 1050
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0002161   F:aminoacyl-tRNA editing activity IEA:InterPro
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0004822   F:isoleucine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006428   P:isoleucyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR001412   aa-tRNA-synth_I_CS.
  IPR002300   aa-tRNA-synth_Ia.
  IPR002301   Ile-tRNA-ligase.
  IPR023585   Ile-tRNA-ligase_type1.
  IPR023586   Ile-tRNA-ligase_type2.
  IPR014729   Rossmann-like_a/b/a_fold.
  IPR009080   tRNAsynth_1a_anticodon-bd.
  IPR013155   V/L/I-tRNA-synth_anticodon-bd.
  IPR009008   Val/Leu/Ile-tRNA-synth_edit.
  PF08264   Anticodon_1.
  PF00133   tRNA-synt_1.
  PS00178   AA_TRNA_LIGASE_I.
  PR00984   TRNASYNTHILE.