UniProt Accession

 LUXS_ECOLI;  P45578;  P77134;  P77805

Genbank Protein ID

 U00096;  AP009048;  U83186;  M86657

Genbank Nucleotide ID

 AAC75734.1;  BAA16549.1;  AAB40286.1

Protein Name

 S-ribosylhomocysteine lyase

Protein Synonyms/Alias

 

Gene Name

 luxS

Gene Synonyms/Alias

 ygaG; OrderedLocusNames=b2687, JW2662

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Autoinducersynthesis; Completeproteome; Directproteinsequencing; Iron; Lyase; Metal-binding; Quorumsensing; Referenceproteome

Protein Sequence

  GO:0005506   F:iron ion binding IEA:InterPro
  GO:0043768   F:S-ribosylhomocysteine lyase activity IDA:EcoCyc
  GO:0010699   P:cell-cell signaling involved in quorum sensing IMP:EcoCyc
  GO:0019284   P:L-methionine biosynthetic process from S-adenosylmethionine IDA:EcoCyc

  IPR011249   Metalloenz_LuxS/M16.
  IPR003815   S-ribosylhomocysteinase.

  PF02664   LuxS.

  PR01487   LUXSPROTEIN.