Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GTP-sensing transcriptional pleiotropic repressor CodY |
Protein Synonyms/Alias | VEG286B |
Gene Name | codY |
Gene Synonyms/Alias | BSU16170 |
Created Date | 3-June-2014 |
Organism | Bacillus subtilis (strain 168) |
NCBI Taxa ID | 224308 |
Phosphorylation | Position | Peptide | Code | Type | References | 215 | DRVGITRSVIVNALR | S | HTP | [1],UniProt | |
Reference | [1]The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Macek B,Mijakovic I,Olsen JV,Gnad F,Kumar C,Jensen PR,Mann M Mol. Cell Proteomics 2007, Apr;6(4):697-707. [ PMID:17218307] |
Functional Description From UniProt | FUNCTION: DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor |
| MOD_RES 215 215 Phosphoserine |
| 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; DNA-binding; GTP-binding; Nucleotide-binding; Phosphoprotein; Referenceproteome; Repressor; Transcription; Transcriptionregulation |
Protein Sequence | MALLQKTRII NSMLQAAAGK PVNFKEMAET LRDVIDSNIF VVSRRGKLLG YSINQQIEND 60 RMKKMLEDRQ FPEEYTKNLF NVPETSSNLD INSEYTAFPV ENRDLFQAGL TTIVPIIGGG 120 ERLGTLILSR LQDQFNDDDL ILAEYGATVV GMEILREKAE EIEEEARSKA VVQMAISSLS 180 YSELEAIEHI FEELDGNEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT 240 YIKVLNNKFL IELENLKSH 259 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0003677 F:DNA binding IEA:UniProtKB-KW GO:0005525 F:GTP binding IEA:UniProtKB-HAMAP GO:0003700 F:sequence-specific DNA binding transcription factor activity IEA:InterPro GO:0045892 P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP GO:0006355 P:regulation of transcription, DNA-templated IMP:CACAO GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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