※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP-sensing transcriptional pleiotropic repressor CodY
Protein Synonyms/Alias
 VEG286B
Gene Name
 codY
Gene Synonyms/Alias
 BSU16170
Created Date
 3-June-2014
Organism
 Bacillus subtilis (strain 168)
NCBI Taxa ID
 224308
Phosphorylation
Position
Peptide
Code
Type
References
215 DRVGITRSVIVNALR S HTP [1],UniProt
Reference
 [1]The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
 Macek B,Mijakovic I,Olsen JV,Gnad F,Kumar C,Jensen PR,Mann M
 Mol. Cell Proteomics 2007, Apr;6(4):697-707. [PMID:17218307]
Functional Description From UniProt
 FUNCTION: DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Sequence Annotation From UniProt
 MOD_RES 215 215 Phosphoserine
Key Word From UniProt
 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; DNA-binding; GTP-binding; Nucleotide-binding; Phosphoprotein; Referenceproteome; Repressor; Transcription; Transcriptionregulation
Protein Sequence
 MALLQKTRII NSMLQAAAGK PVNFKEMAET LRDVIDSNIF VVSRRGKLLG YSINQQIEND 60
 RMKKMLEDRQ FPEEYTKNLF NVPETSSNLD INSEYTAFPV ENRDLFQAGL TTIVPIIGGG 120
 ERLGTLILSR LQDQFNDDDL ILAEYGATVV GMEILREKAE EIEEEARSKA VVQMAISSLS 180
 YSELEAIEHI FEELDGNEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT 240
 YIKVLNNKFL IELENLKSH 259
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0005525   F:GTP binding IEA:UniProtKB-HAMAP
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0045892   P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP
  GO:0006355   P:regulation of transcription, DNA-templated IMP:CACAO
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR014154   GTP_sensing_CodY.
  IPR010312   GTP_sensing_CodY_N.
  IPR013198   GTP_sensing_HTH_CodY_C.
  IPR011991   WHTH_DNA-bd_dom.
  PF06018   CodY.
  PF08222   HTH_CodY.