※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sulfite reductase [NADPH] flavoprotein alpha-component
Protein Synonyms/Alias
 SiR-FP
Gene Name
 cysJ
Gene Synonyms/Alias
 b2764, JW2734
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
207 RVVDALKSRAPVAAP S HTP [1]
231 NEIHTSPYSKDAPLV Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Amino-acidbiosynthesis; Completeproteome; Cysteinebiosynthesis; Directproteinsequencing; Electrontransport; FAD; Flavoprotein; FMN; NADP; Oxidoreductase; Referenceproteome; Transport
Protein Sequence
 MTTQVPPSAL LPLNPEQLAR LQAATTDLTP TQLAWVSGYF WGVLNQQPAA LAATPAPAAE 60
 MPGITIISAS QTGNARRVAE ALRDDLLAAK LNVKLVNAGD YKFKQIASEK LLIVVTSTQG 120
 EGEPPEEAVA LHKFLFSKKA PKLENTAFAV FSLGDSSYEF FCQSGKDFDS KLAELGGERL 180
 LDRVDADVEY QAAASEWRAR VVDALKSRAP VAAPSQSVAT GAVNEIHTSP YSKDAPLVAS 240
 LSVNQKITGR NSEKDVRHIE IDLGDSGMRY QPGDALGVWY QNDPALVKEL VELLWLKGDE 300
 PVTVEGKTLP LNEALQWHFE LTVNTANIVE NYATLTRSET LLPLVGDKAK LQHYAATTPI 360
 VDMVRFSPAQ LDAEALINLL RPLTPRLYSI ASSQAEVENE VHVTVGVVRY DVEGRARAGG 420
 ASSFLADRVE EEGEVRVFIE HNDNFRLPAN PETPVIMIGP GTGIAPFRAF MQQRAADEAP 480
 GKNWLFFGNP HFTEDFLYQV EWQRYVKDGV LTRIDLAWSR DQKEKVYVQD KLREQGAELW 540
 RWINDGAHIY VCGDANRMAK DVEQALLEVI AEFGGMDTEA ADEFLSELRV ERRYQRDVY 599
  GO:0009337   C:sulfite reductase complex (NADPH) IDA:EcoCyc
  GO:0050660   F:flavin adenine dinucleotide binding IDA:EcoCyc
  GO:0010181   F:FMN binding IDA:EcoCyc
  GO:0005506   F:iron ion binding IEA:InterPro
  GO:0003958   F:NADPH-hemoprotein reductase activity IBA:RefGenome
  GO:0016709   F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IBA:RefGenome
  GO:0042602   F:riboflavin reductase (NADPH) activity IDA:EcoCyc
  GO:0004783   F:sulfite reductase (NADPH) activity IEA:UniProtKB-HAMAP
  GO:0019344   P:cysteine biosynthetic process IEA:UniProtKB-KW
  GO:0070814   P:hydrogen sulfide biosynthetic process IEA:UniProtKB-HAMAP
  GO:0000103   P:sulfate assimilation IEA:UniProtKB-HAMAP
  IPR010199   CysJ.
  IPR003097   FAD-binding_1.
  IPR017927   Fd_Rdtase_FAD-bd.
  IPR001094   Flavdoxin.
  IPR008254   Flavodoxin/NO_synth.
  IPR001709   Flavoprot_Pyr_Nucl_cyt_Rdtase.
  IPR023173   NADPH_Cyt_P450_Rdtase_dom3.
  IPR001433   OxRdtase_FAD/NAD-bd.
  IPR017938   Riboflavin_synthase-like_b-brl.
  PF00667   FAD_binding_1.
  PF00258   Flavodoxin_1.
  PF00175   NAD_binding_1.
  PS51384   FAD_FR.
  PS50902   FLAVODOXIN_LIKE.
  PR00369   FLAVODOXIN.
  PR00371   FPNCR.