※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glyoxylate/hydroxypyruvate reductase B
Protein Synonyms/Alias
 2KR
Gene Name
 ghrB
Gene Synonyms/Alias
 tkrA, yiaE; OrderedLocusNames=b3553, JW5656
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
228 EQFAKMKSSAIFINA S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D- gluconate (5KDG), 2-keto-D-gluconate (2KDG) to D-gluconate, and 2- keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function. Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D-fructose and L- sorbose. Activity with NAD is very low
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Cytoplasm; Directproteinsequencing; Gluconateutilization; NAD; NADP; Oxidoreductase; Referenceproteome
Protein Sequence
 MKPSVILYKA LPDDLLQRLQ EHFTVHQVAN LSPQTVEQNA AIFAEAEGLL GSNENVNAAL 60
 LEKMPKLRAT STISVGYDNF DVDALTARKI LLMHTPTVLT ETVADTLMAL VLSTARRVVE 120
 VAERVKAGEW TASIGPDWYG TDVHHKTLGI VGMGRIGMAL AQRAHFGFNM PILYNARRHH 180
 KEAEERFNAR YCDLDTLLQE SDFVCLILPL TDETHHLFGA EQFAKMKSSA IFINAGRGPV 240
 VDENALIAAL QKGEIHAAGL DVFEQEPLSV DSPLLSMANV VAVPHIGSAT HETRYGMAAC 300
 AVDNLIDALQ GKVEKNCVNP HVAD 324
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005886   C:plasma membrane IEA:UniProtKB-HAMAP
  GO:0008873   F:gluconate 2-dehydrogenase activity IDA:EcoCyc
  GO:0030267   F:glyoxylate reductase (NADP) activity IDA:EcoCyc
  GO:0016618   F:hydroxypyruvate reductase activity IEA:UniProtKB-HAMAP
  GO:0051287   F:NAD binding IEA:InterPro
  GO:0019521   P:D-gluconate metabolic process IEA:UniProtKB-KW
  GO:0046181   P:ketogluconate catabolic process IMP:EcoCyc
  IPR006139   D-isomer_2_OHA_DH_cat_dom.
  IPR006140   D-isomer_2_OHA_DH_NAD-bd.
  IPR023756   Glyo/OHPyrv_Rdtase_B.
  IPR016040   NAD(P)-bd_dom.
  PF00389   2-Hacid_dh.
  PF02826   2-Hacid_dh_C.
  PS00670   D_2_HYDROXYACID_DH_2.
  PS00671   D_2_HYDROXYACID_DH_3.