※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulatory protein BasR
Protein Synonyms/Alias
 
Gene Name
 basR
Gene Synonyms/Alias
 parA, pmrA; OrderedLocusNames=STM4292
Created Date
 3-June-2014
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
NCBI Taxa ID
 99287
Phosphorylation
Position
Peptide
Code
Type
References
51 HYSLMVLDLGLPDED D LTP [1],UniProt
Reference
 [1]A small protein that mediates the activation of a two-component system by another two-component system.
 Kox LF,Wösten MM,Groisman EA
 EMBO J. 2000, Apr, 17;19(8):1861-72. [PMID:10775270]
Functional Description From UniProt
 FUNCTION: Member of the two-component regulatory system BasS/BasR BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well
Sequence Annotation From UniProt
 MOD_RES 51 51 4-aspartylphosphate
Key Word From UniProt
 Activator; Antibioticresistance; Completeproteome; Cytoplasm; DNA-binding; Phosphoprotein; Referenceproteome; Repressor; Transcription; Transcriptionregulation; Two-componentregulatorysystem; Virulence
Protein Sequence
 MKILIVEDDT LLLQGLILAA QTEGYACDGV STARAAEHSL ESGHYSLMVL DLGLPDEDGL 60
 HFLTRIRQKK YTLPVLILTA HDTLNDRITG LDVGADDYLV KPFALEELHA RIRALLRRHN 120
 NQGESELTVG NLTLNIGRHQ AWRDGQELTL TPKEYALLSR LMLKAGSPVH REILYNDIYN 180
 WDNEPSTNTL EVHIHNLRDK VGKSRIRTVR GFGYMLVATE ES 222
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0009405   P:pathogenesis IEA:UniProtKB-KW
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0046677   P:response to antibiotic IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR011006   CheY-like_superfamily.
  IPR001867   Sig_transdc_resp-reg_C.
  IPR016032   Sig_transdc_resp-reg_C-effctor.
  IPR001789   Sig_transdc_resp-reg_receiver.
  IPR011991   WHTH_DNA-bd_dom.
  PF00072   Response_reg.
  PF00486   Trans_reg_C.
  SM00448   REC.
  SM00862   Trans_reg_C.
  PS50110   RESPONSE_REGULATORY.