Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional regulatory protein BasR |
Protein Synonyms/Alias | |
Gene Name | basR |
Gene Synonyms/Alias | parA, pmrA; OrderedLocusNames=STM4292 |
Created Date | 3-June-2014 |
Organism | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
NCBI Taxa ID | 99287 |
Phosphorylation | Position | Peptide | Code | Type | References | 51 | HYSLMVLDLGLPDED | D | LTP | [1],UniProt | |
Reference | [1]A small protein that mediates the activation of a two-component system by another two-component system. Kox LF,Wösten MM,Groisman EA EMBO J. 2000, Apr, 17;19(8):1861-72. [ PMID:10775270] |
Functional Description From UniProt | FUNCTION: Member of the two-component regulatory system BasS/BasR BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well |
| MOD_RES 51 51 4-aspartylphosphate |
| Activator; Antibioticresistance; Completeproteome; Cytoplasm; DNA-binding; Phosphoprotein; Referenceproteome; Repressor; Transcription; Transcriptionregulation; Two-componentregulatorysystem; Virulence |
Protein Sequence | MKILIVEDDT LLLQGLILAA QTEGYACDGV STARAAEHSL ESGHYSLMVL DLGLPDEDGL 60 HFLTRIRQKK YTLPVLILTA HDTLNDRITG LDVGADDYLV KPFALEELHA RIRALLRRHN 120 NQGESELTVG NLTLNIGRHQ AWRDGQELTL TPKEYALLSR LMLKAGSPVH REILYNDIYN 180 WDNEPSTNTL EVHIHNLRDK VGKSRIRTVR GFGYMLVATE ES 222 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0003677 F:DNA binding IEA:UniProtKB-KW GO:0000156 F:phosphorelay response regulator activity IEA:InterPro GO:0009405 P:pathogenesis IEA:UniProtKB-KW GO:0006355 P:regulation of transcription, DNA-templated IEA:UniProtKB-KW GO:0046677 P:response to antibiotic IEA:UniProtKB-KW GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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