※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator SgrR
Protein Synonyms/Alias
 
Gene Name
 sgrR
Gene Synonyms/Alias
 yabN; OrderedLocusNames=b0069, JW0068
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
126 RHILRVLYYRPLRNL Y HTP [1]
336 SRLEEGCYYLLFDSR Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain
Sequence Annotation From UniProt
 
Key Word From UniProt
 Activator; Completeproteome; DNA-binding; Referenceproteome; Repressor; Transcription; Transcriptionregulation
Protein Sequence
 MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG 60
 RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH 120
 ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW 180
 RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP 240
 LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN 300
 VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL 360
 SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG LESLTLTFYQ DHSEHRVIAG 420
 IMQQILASHQ VTLKIKEIDY DQWHTGEIES DIWLNSANFT LPLDFSVFAH LCEVPLLQHC 480
 IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLLHHWL IIQGQRSMRG LRMNTLGWFD 540
 FKSAWFAPPD P 551
  GO:0003677   F:DNA binding IEA:UniProtKB-HAMAP
  GO:0005215   F:transporter activity IEA:InterPro
  GO:0045892   P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP
  GO:0045893   P:positive regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR000914   SBP_bac_5.
  IPR025370   SgrR_HTH_N.
  IPR023767   Tscrpt_reg_SgrR.
  PF00496   SBP_bac_5.
  PF12793   SgrR_N.