※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Multiphosphoryl transfer protein 2
Protein Synonyms/Alias
 MTP 2;  Protein H
Gene Name
 ptsA
Gene Synonyms/Alias
 frwA, yijH; OrderedLocusNames=b3947, JW5555
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
669 NQAMACRTSLEVEHL T HTP [1]
670 QAMACRTSLEVEHLL S HTP [1]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 FUNCTION: Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). HPr transfers the phosphoryl group to the phosphoryl carrier EIIA, which then transfers it to EIIB (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Phosphoprotein; Phosphotransferasesystem; Referenceproteome; Sugartransport; Transferase; Transport
Protein Sequence
 MALIVEFICE LPNGVHARPA SHVETLCNTF SSQIEWHNLR TDRKGNAKSA LALIGTDTLA 60
 GDNCQLLISG ADEQEAHQRL SQWLRDEFPH CDAPLAEVKS DELEPLPVSL TNLNPQIIRA 120
 RTVCSGSAGG ILTPISSLDL NALGNLPAAK GVDAEQSALE NGLTLVLKNI EFRLLDSDGA 180
 TSAILEAHRS LAGDTSLREH LLAGVSAGLS CAEAIVASAN HFCEEFSRSS SSYLQERALD 240
 VRDVCFQLLQ QIYGEQRFPA PGKLTQPAIC MADELTPSQF LELDKNHLKG LLLKSGGTTS 300
 HTVILARSFN IPTLVGVDID ALTPWQQQTI YIDGNAGAIV VEPGEAVARY YQQEARVQDA 360
 LREQQRVWLT QQARTADGIR IEIAANIAHS VEAQAAFGNG AEGVGLFRTE MLYMDRTSAP 420
 GESELYNIFC QALESANGRS IIVRTMDIGG DKPVDYLNIP AEANPFLGYR AVRIYEEYAS 480
 LFTTQLRSIL RASAHGSLKI MIPMISSMEE ILWVKEKLAE AKQQLRNEHI PFDEKIQLGI 540
 MLEVPSVMFI IDQCCEEIDF FSIGSNDLTQ YLLAVDRDNA KVTRHYNSLN PAFLRALDYA 600
 VQAVHRQGKW IGLCGELGAK GSVLPLLVGL GLDELSMSAP SIPAAKARMA QLDSRECRKL 660
 LNQAMACRTS LEVEHLLAQF RMTQQDAPLV TAECITLESD WRSKEEVLKG MTDNLLLAGR 720
 CRYPRKLEAD LWAREAVFST GLGFSFAIPH SKSEHIEQST ISVARLQAPV RWGDDEAQFI 780
 IMLTLNKHAA GDQHMRIFSR LARRIMHEEF RNALVNAASA DAIASLLQHE LEL 833
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0016301   F:kinase activity IEA:UniProtKB-KW
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0008965   F:phosphoenolpyruvate-protein phosphotransferase activity IEA:UniProtKB-EC
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IEA:UniProtKB-KW
  IPR000032   HPr_prot-like.
  IPR008279   PEP-util_enz_mobile_dom.
  IPR018274   PEP_util_AS.
  IPR000121   PEP_util_C.
  IPR023151   PEP_util_CS.
  IPR006318   PEP_util_enz.
  IPR016152   PTrfase/Anion_transptr.
  IPR002178   PTS_EIIA_type-2_dom.
  IPR008731   PTS_EIN.
  IPR001020   PTS_HPr_His_P_site.
  IPR015813   Pyrv/PenolPyrv_Kinase-like_dom.
  PF05524   PEP-utilisers_N.
  PF00391   PEP-utilizers.
  PF02896   PEP-utilizers_C.
  PF00381   PTS-HPr.
  PF00359   PTS_EIIA_2.
  PS00742   PEP_ENZYMES_2.
  PS00370   PEP_ENZYMES_PHOS_SITE.
  PS51094   PTS_EIIA_TYPE_2.
  PS51350   PTS_HPR_DOM.
  PS00369   PTS_HPR_HIS.
  PR01736   PHPHTRNFRASE.