※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-isopropylmalate dehydrogenase
Protein Synonyms/Alias
 IMDH
Gene Name
 leuB
Gene Synonyms/Alias
 b0073, JW5807
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
155 QPKGREGSGQYEKAF S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Amino-acidbiosynthesis; Branched-chainaminoacidbiosynthesis; Completeproteome; Cytoplasm; Directproteinsequencing; Leucinebiosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase; Referenceproteome
Protein Sequence
 MSKNYHIAVL PGDGIGPEVM TQALKVLDAV RNRFAMRITT SHYDVGGAAI DNHGQPLPPA 60
 TVEGCEQADA VLFGSVGGPK WEHLPPDQQP ERGALLPLRK HFKLFSNLRP AKLYQGLEAF 120
 CPLRADIAAN GFDILCVREL TGGIYFGQPK GREGSGQYEK AFDTEVYHRF EIERIARIAF 180
 ESARKRRHKV TSIDKANVLQ SSILWREIVN EIATEYPDVE LAHMYIDNAT MQLIKDPSQF 240
 DVLLCSNLFG DILSDECAMI TGSMGMLPSA SLNEQGFGLY EPAGGSAPDI AGKNIANPIA 300
 QILSLALLLR YSLDADDAAC AIERAINRAL EEGIRTGDLA RGAAAVSTDE MGDIIARYVA 360
 EGV 363
  GO:0005829   C:cytosol EXP:EcoCyc
  GO:0003862   F:3-isopropylmalate dehydrogenase activity IDA:EcoCyc
  GO:0000287   F:magnesium ion binding IDA:EcoCyc
  GO:0030145   F:manganese ion binding IDA:EcoCyc
  GO:0046872   F:metal ion binding IDA:EcoCyc
  GO:0051287   F:NAD binding IEA:InterPro
  GO:0034198   P:cellular response to amino acid starvation IMP:EcoliWiki
  GO:0009098   P:leucine biosynthetic process IDA:EcoCyc
  IPR019818   IsoCit/isopropylmalate_DH_CS.
  IPR001804   Isocitrate/isopropylmalate_DH.
  IPR024084   IsoPropMal-DH-like_dom.
  IPR004429   Isopropylmalate_DH.
  PF00180   Iso_dh.
  PS00470   IDH_IMDH.