UniProt Accession

 PTHP_STRSL;  P24366

Genbank Protein ID

 Z17217;  M81756

Genbank Nucleotide ID

 CAA78923.1

Protein Name

 Phosphocarrier protein HPr

Protein Synonyms/Alias

 

Gene Name

 ptsH

Gene Synonyms/Alias

 

Created Date

 3-June-2014

Organism

 Streptococcus salivarius

NCBI Taxa ID

 1304

Phosphorylation

Reference

 [1]The HPr(Ser) kinase of Streptococcus salivarius: purification, properties, and cloning of the hprK gene.
 Brochu D,Vadeboncoeur C
 J. Bacteriol. 1999, Feb;181(3):709-17. [PMID:9922231]

Functional Description From UniProt

 FUNCTION: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)

Sequence Annotation From UniProt

 MOD_RES 46 46 Phosphoserine; by HPrK/P

Key Word From UniProt

 Cytoplasm; Directproteinsequencing; Kinase; Phosphoprotein; Phosphotransferasesystem; Serine/threonine-proteinkinase; Sugartransport; Transcription; Transcriptionregulation; Transferase; Transport

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IEA:UniProtKB-KW
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR000032   HPr_prot-like.
  IPR001020   PTS_HPr_His_P_site.
  IPR002114   PTS_HPr_Ser_P_site.

  PF00381   PTS-HPr.

  PS51350   PTS_HPR_DOM.
  PS00369   PTS_HPR_HIS.
  PS00589   PTS_HPR_SER.

  PR00107   PHOSPHOCPHPR.