※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
Protein Synonyms/Alias
 
Gene Name
 msbB
Gene Synonyms/Alias
 b1855, JW1844
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
8 METKKNNSEYIPEFD S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA. Decanoyl, palmitoyl, palmitoleoyl, and (R)-3-hydroxymyristoyl-ACP are poor acyl donors. Functions optimally after laurate incorporation by HtrB has taken place. Acylates (KDO)2-(lauroyl)-lipid IVA about 100 times faster than (KDO)2-lipid IVA. Displays a preference for myristoyl-ACP over lauroyl-ACP
Sequence Annotation From UniProt
 TRANSMEM 23 43 Helical; (Potential)
Key Word From UniProt
 Acyltransferase; Cellinnermembrane; Cellmembrane; Completeproteome; Lipopolysaccharidebiosynthesis; Membrane; Referenceproteome; Transferase; Transmembrane; Transmembranehelix
Protein Sequence
 METKKNNSEY IPEFDKSFRH PRYWGAWLGV AAMAGIALTP PKFRDPILAR LGRFAGRLGK 60
 SSRRRALINL SLCFPERSEA EREAIVDEMF ATAPQAMAMM AELAIRGPEK IQPRVDWQGL 120
 EIIEEMRRNN EKVIFLVPHG WAVDIPAMLM ASQGQKMAAM FHNQGNPVFD YVWNTVRRRF 180
 GGRLHARNDG IKPFIQSVRQ GYWGYYLPDQ DHGPEHSEFV DFFATYKATL PAIGRLMKVC 240
 RARVVPLFPI YDGKTHRLTI QVRPPMDDLL EADDHTIARR MNEEVEIFVG PRPEQYTWIL 300
 KLLKTRKPGE IQPYKRKDLY PIK 323
  GO:0009276   C:Gram-negative-bacterium-type cell wall IEA:InterPro
  GO:0016021   C:integral component of membrane IEA:UniProtKB-KW
  GO:0005886   C:plasma membrane IEA:UniProtKB-SubCell
  GO:0016747   F:transferase activity, transferring acyl groups other than amino-acyl groups IDA:EcoCyc
  GO:0036104   P:Kdo2-lipid A biosynthetic process IDA:EcoCyc
  GO:0009244   P:lipopolysaccharide core region biosynthetic process IEA:InterPro
  IPR004960   LipA_acyltrans.
  IPR011921   Lipid_A_MsbB.
  PF03279   Lip_A_acyltrans.