※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulatory protein PhoP
Protein Synonyms/Alias
 
Gene Name
 phoP
Gene Synonyms/Alias
 b1130, JW1116
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
98 LSAGADDYVTKPFHI Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes
Sequence Annotation From UniProt
 MOD_RES 51 51 4-aspartylphosphate (By similarity)
Key Word From UniProt
 3D-structure; Activator; Completeproteome; Cytoplasm; Directproteinsequencing; DNA-binding; Phosphoprotein; Referenceproteome; Repressor; Transcription; Transcriptionregulation; Two-componentregulatorysystem
Protein Sequence
 MRVLVVEDNA LLRHHLKVQI QDAGHQVDDA EDAKEADYYL NEHIPDIAIV DLGLPDEDGL 60
 SLIRRWRSND VSLPILVLTA RESWQDKVEV LSAGADDYVT KPFHIEEVMA RMQALMRRNS 120
 GLASQVISLP PFQVDLSRRE LSINDEVIKL TAFEYTIMET LIRNNGKVVS KDSLMLQLYP 180
 DAELRESHTI DVLMGRLRKK IQAQYPQEVI TTVRGQGYLF ELR 223
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR011006   CheY-like_superfamily.
  IPR001867   Sig_transdc_resp-reg_C.
  IPR001789   Sig_transdc_resp-reg_receiver.
  IPR011991   WHTH_DNA-bd_dom.
  PF00072   Response_reg.
  PF00486   Trans_reg_C.
  SM00448   REC.
  SM00862   Trans_reg_C.
  PS50110   RESPONSE_REGULATORY.