※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoenolpyruvate synthase
Protein Synonyms/Alias
 PEP synthase
Gene Name
 ppsA
Gene Synonyms/Alias
 pps; OrderedLocusNames=b1702, JW1692
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
419 VTNRGGRTCHAAIIA T HTP [1]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 FUNCTION: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
Sequence Annotation From UniProt
 
Key Word From UniProt
 ATP-binding; Completeproteome; Directproteinsequencing; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Referenceproteome; Transferase
Protein Sequence
 MSNNGSSPLV LWYNQLGMND VDRVGGKNAS LGEMITNLSG MGVSVPNGFA TTADAFNQFL 60
 DQSGVNQRIY ELLDKTDIDD VTQLAKAGAQ IRQWIIDTPF QPELENAIRE AYAQLSADDE 120
 NASFAVRSSA TAEDMPDASF AGQQETFLNV QGFDAVLVAV KHVFASLFND RAISYRVHQG 180
 YDHRGVALSA GVQRMVRSDL ASSGVMFSID TESGFDQVVF ITSAWGLGEM VVQGAVNPDE 240
 FYVHKPTLAA NRPAIVRRTM GSKKIRMVYA PTQEHGKQVK IEDVPQEQRD IFSLTNEEVQ 300
 ELAKQAVQIE KHYGRPMDIE WAKDGHTGKL FIVQARPETV RSRGQVMERY TLHSQGKIIA 360
 EGRAIGHRIG AGPVKVIHDI SEMNRIEPGD VLVTDMTDPD WEPIMKKASA IVTNRGGRTC 420
 HAAIIARELG IPAVVGCGDA TERMKDGENV TVSCAEGDTG YVYAELLEFS VKSSSVETMP 480
 DLPLKVMMNV GNPDRAFDFA CLPNEGVGLA RLEFIINRMI GVHPRALLEF DDQEPQLQNE 540
 IREMMKGFDS PREFYVGRLT EGIATLGAAF YPKRVIVRLS DFKSNEYANL VGGERYEPDE 600
 ENPMLGFRGA GRYVSDSFRD CFALECEAVK RVRNDMGLTN VEIMIPFVRT VDQAKAVVEE 660
 LARQGLKRGE NGLKIIMMCE IPSNALLAEQ FLEYFDGFSI GSNDMTQLAL GLDRDSGVVS 720
 ELFDERNDAV KALLSMAIRA AKKQGKYVGI CGQGPSDHED FAAWLMEEGI DSLSLNPDTV 780
 VQTWLSLAEL KK 792
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0000287   F:magnesium ion binding IDA:EcoCyc
  GO:0008986   F:pyruvate, water dikinase activity IDA:EcoCyc
  GO:0006094   P:gluconeogenesis IMP:EcoCyc
  GO:0006090   P:pyruvate metabolic process IEA:InterPro
  IPR013815   ATP_grasp_subdomain_1.
  IPR013816   ATP_grasp_subdomain_2.
  IPR008279   PEP-util_enz_mobile_dom.
  IPR006319   PEP_synth.
  IPR018274   PEP_util_AS.
  IPR000121   PEP_util_C.
  IPR023151   PEP_util_CS.
  IPR002192   PPDK_PEP-bd.
  IPR015813   Pyrv/PenolPyrv_Kinase-like_dom.
  PF00391   PEP-utilizers.
  PF02896   PEP-utilizers_C.
  PF01326   PPDK_N.
  PS00742   PEP_ENZYMES_2.
  PS00370   PEP_ENZYMES_PHOS_SITE.