※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 2
Protein Synonyms/Alias
 EF-2
Gene Name
 fusA
Gene Synonyms/Alias
 fus; OrderedLocusNames=Saci_0603
Created Date
 3-June-2014
Organism
 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
NCBI Taxa ID
 330779
Phosphorylation
Position
Peptide
Code
Type
References
487 SQVFEGKSPNKHNKL S HTP [1]
159 LIKELKLSSQEIQKR S HTP [1]
480 RESIRNKSQVFEGKS S HTP [1]
160 IKELKLSSQEIQKRL S HTP [1]
Reference
 [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius.
 Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV
 Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [PMID:24078887]
Functional Description From UniProt
 FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Sequence Annotation From UniProt
 MOD_RES 604 604 Diphthamide (By similarity)
Key Word From UniProt
 Completeproteome; Cytoplasm; Directproteinsequencing; Elongationfactor; GTP-binding; Nucleotide-binding; Proteinbiosynthesis
Protein Sequence
 MPRYKTVEQV LSLMKDVTRV RNIGIIAHVD HGKTTTSDTL LAASGIISQK VAGEALALDY 60
 LSVEQQRGIT VKAANISLYH EIDGKGYVIN LIDTPGHVDF SGRVTRSLRV LDGSIVVIDA 120
 VEGIMTQTET VLRQSLEERV RPILFINKVD RLIKELKLSS QEIQKRLIDL IIEVNNLIET 180
 YGEPEFKDQW KIKPELGNVV FGSAKDKWGF SVPMAGKRGV KFSDVVNAYT SGDKAKIEEL 240
 ASKVPIHEAL LDAVIKFVPN PRDSQKYRIP KIWKGDLDSE IAKAMINADP NGPIVMMIND 300
 MKVDPHAGLV ATGRVFSGTL RAGEEVWLVN AKRQQRILQV SLYMGAIREL AEEIPVGNIA 360
 AALGMDAARS GETGVDIRFK DSVLGSFEKL HYISEPVVTI SVEPRNPKDL TKMIDALRKL 420
 SIEDSNLVVK INEETGEYLL SGMGFLHLEV SLQLLKENYG LDVVTTPPIV VYRESIRNKS 480
 QVFEGKSPNK HNKLYISVEP LNNQTIDLIA NGTIKEDMDN KEMAKILRDQ AEWDYDEAKK 540
 IVAIDENINV FIDATSGVQH LREIMDTLLQ GFRLAMKEGP LAFEPVRGVK VVLHDAVVHE 600
 DPAHRGPAQL YPAVRNAIFA GILTSKPTLL EPLQKLDIRI PMEYLGNVTA VITRKRGKVI 660
 NVVQTGNVAR VYAEIPVGES FELASELRAS SAGRAFWGTE FSRWAPVPDS ILVDLIMKIR 720
 ERKGKPKQLP KVEDFIS 737
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005525   F:GTP binding IEA:UniProtKB-HAMAP
  GO:0003924   F:GTPase activity IEA:InterPro
  GO:0003746   F:translation elongation factor activity IEA:UniProtKB-HAMAP
  IPR000795   EF_GTP-bd_dom.
  IPR009022   EFG_III-V.
  IPR000640   EFG_V.
  IPR027417   P-loop_NTPase.
  IPR020568   Ribosomal_S5_D2-typ_fold.
  IPR014721   Ribosomal_S5_D2-typ_fold_subgr.
  IPR005225   Small_GTP-bd_dom.
  IPR009000   Transl_B-barrel.
  IPR004543   Transl_elong_EFG/EF2_arc.
  IPR005517   Transl_elong_EFG/EF2_IV.
  IPR004161   Transl_elong_EFTu/EF1A_2.
  PF00679   EFG_C.
  PF14492   EFG_II.
  PF03764   EFG_IV.
  PF00009   GTP_EFTU.
  PF03144   GTP_EFTU_D2.
  SM00838   EFG_C.
  SM00889   EFG_IV.
  PS00301   EFACTOR_GTP.
  PR00315   ELONGATNFCT.