| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Xaa-Pro dipeptidase |
Protein Synonyms/Alias | X-Pro dipeptidase; Prolidase |
Gene Name | pepQ |
Gene Synonyms/Alias | b3847, JW3823 |
Created Date | 3-June-2014 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Phosphorylation | Position | Peptide | Code | Type | References | | 266 | TRTWSAKSDNDYAQL | S | HTP | [1] | |
Reference | [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium. Soares NC,Spät P,Krug K,Macek B J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [ PMID:23590516] |
Functional Description From UniProt | FUNCTION: Splits dipeptides with a prolyl residue in the C- terminal position and a polar or nonpolar amino acid at the N- terminal position. With much lower efficiency, also catalyzes the stereoselective hydrolysis of a wide variety of organophosphate triesters and organophosphonate diesters. Is able to hydrolyze the organophosphorus insecticide paraoxon and the p-nitrophenyl analogs of the nerve agents GB (sarin), GD (soman), GF, Vx and rVX |
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| Completeproteome; Dipeptidase; Directproteinsequencing; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Referenceproteome |
Protein Sequence | MESLASLYKN HIATLQERTR DALARFKLDA LLIHSGELFN VFLDDHPYPF KVNPQFKAWV 60
PVTQVPNCWL LVDGVNKPKL WFYLPVDYWH NVEPLPTSFW TEDVEVIALP KADGIGSLLP 120
AARGNIGYIG PVPERALQLG IEASNINPKG VIDYLHYYRS FKTEYELACM REAQKMAVNG 180
HRAAEEAFRS GMSEFDINIA YLTATGHRDT DVPYSNIVAL NEHAAVLHYT KLDHQAPEEM 240
RSFLLDAGAE YNGYAADLTR TWSAKSDNDY AQLVKDVNDE QLALIATMKA GVSYVDYHIQ 300
FHQRIAKLLR KHQIITDMSE EAMVENDLTG PFMPHGIGHP LGLQVHDVAG FMQDDSGTHL 360
AAPAKYPYLR CTRILQPGMV LTIEPGIYFI ESLLAPWREG QFSKHFNWQK IEALKPFGGI 420
RIEDNVVIHE NNVENMTRDL KLA 443 |
| GO:0016805 F:dipeptidase activity IDA:EcoCyc GO:0046872 F:metal ion binding IEA:UniProtKB-KW GO:0008235 F:metalloexopeptidase activity IEA:UniProtKB-HAMAP GO:0016795 F:phosphoric triester hydrolase activity IEA:InterPro GO:0043171 P:peptide catabolic process IGI:EcoliWiki |
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