※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA ligase
Protein Synonyms/Alias
 
Gene Name
 ligA
Gene Synonyms/Alias
 dnaL, lig, lop, pdeC
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
492 LERMGPKSAQNVVNA S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Directproteinsequencing; DNAdamage; DNArepair; DNAreplication; Ligase; Magnesium; Metal-binding; NAD; Referenceproteome; Zinc
Protein Sequence
 MESIEQQLTE LRTTLRHHEY LYHVMDAPEI PDAEYDRLMR ELRELETKHP ELITPDSPTQ 60
 RVGAAPLAAF SQIRHEVPML SLDNVFDEES FLAFNKRVQD RLKNNEKVTW CCELKLDGLA 120
 VSILYENGVL VSAATRGDGT TGEDITSNVR TIRAIPLKLH GENIPARLEV RGEVFLPQAG 180
 FEKINEDARR TGGKVFANPR NAAAGSLRQL DPRITAKRPL TFFCYGVGVL EGGELPDTHL 240
 GRLLQFKKWG LPVSDRVTLC ESAEEVLAFY HKVEEDRPTL GFDIDGVVIK VNSLAQQEQL 300
 GFVARAPRWA VAFKFPAQEQ MTFVRDVEFQ VGRTGAITPV ARLEPVHVAG VLVSNATLHN 360
 ADEIERLGLR IGDKVVIRRA GDVIPQVVNV VLSERPEDTR EVVFPTHCPV CGSDVERVEG 420
 EAVARCTGGL ICGAQRKESL KHFVSRRAMD VDGMGDKIID QLVEKEYVHT PADLFKLTAG 480
 KLTGLERMGP KSAQNVVNAL EKAKETTFAR FLYALGIREV GEATAAGLAA YFGTLEALEA 540
 ASIEELQKVP DVGIVVASHV HNFFAEESNR NVISELLAEG VHWPAPIVIN AEEIDSPFAG 600
 KTVVLTGSLS QMSRDDAKAR LVELGAKVAG SVSKKTDLVI AGEAAGSKLA KAQELGIEVI 660
 DEAEMLRLLG S 671
  GO:0005829   C:cytosol IDA:EcoCyc
  GO:0003677   F:DNA binding IDA:EcoCyc
  GO:0003911   F:DNA ligase (NAD+) activity IDA:EcoCyc
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0070403   F:NAD+ binding IMP:EcoCyc
  GO:0006288   P:base-excision repair, DNA ligation IDA:EcoCyc
  GO:0006266   P:DNA ligation IDA:EcoCyc
  GO:0006260   P:DNA replication IEA:UniProtKB-KW
  IPR001357   BRCT_dom.
  IPR018239   DNA_ligase_AS.
  IPR001679   DNAligase.
  IPR013839   DNAligase_adenylation.
  IPR013840   DNAligase_N.
  IPR003583   Hlx-hairpin-Hlx_DNA-bd_motif.
  IPR012340   NA-bd_OB-fold.
  IPR004150   NAD_DNA_ligase_OB.
  IPR010994   RuvA_2-like.
  IPR004149   Znf_DNAligase_C4.
  PF00533   BRCT.
  PF01653   DNA_ligase_aden.
  PF03120   DNA_ligase_OB.
  PF03119   DNA_ligase_ZBD.
  SM00292   BRCT.
  SM00278   HhH1.
  SM00532   LIGANc.
  PS50172   BRCT.
  PS01055   DNA_LIGASE_N1.
  PS01056   DNA_LIGASE_N2.