※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transduction histidine-protein kinase/phosphatase DegS
Protein Synonyms/Alias
 
Gene Name
 degS
Gene Synonyms/Alias
 sacU; OrderedLocusNames=BSU35500
Created Date
 3-June-2014
Organism
 Bacillus subtilis (strain 168)
NCBI Taxa ID
 224308
Phosphorylation
Position
Peptide
Code
Type
References
76 RHARNRLSEVSRNFH S HTP [1],UniProt
Reference
 [1]The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
 Macek B,Mijakovic I,Olsen JV,Gnad F,Kumar C,Jensen PR,Mann M
 Mol. Cell Proteomics 2007, Apr;6(4):697-707. [PMID:17218307]
Functional Description From UniProt
 FUNCTION: Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho- DegU
Sequence Annotation From UniProt
 COILED 31 141 Potential
 MOD_RES 76 76 Phosphoserine
 MOD_RES 189 189 Phosphohistidine; by autocatalysis (By similarity)
Key Word From UniProt
 ATP-binding; Coiledcoil; Completeproteome; Cytoplasm; Hydrolase; Kinase; Nucleotide-binding; Phosphoprotein; Proteinphosphatase; Referenceproteome; Transferase; Two-componentregulatorysystem
Protein Sequence
 MNKTKMDSKV LDSILMKMLK TVDGSKDEVF QIGEQSRQQY EQLVEELKQI KQQVYEVIEL 60
 GDKLEVQTRH ARNRLSEVSR NFHRFSEEEI RNAYEKAHKL QVELTMIQQR EKQLRERRDD 120
 LERRLLGLQE IIERSESLVS QITVVLNYLN QDLREVGLLL ADAQAKQDFG LRIIEAQEEE 180
 RKRVSREIHD GPAQMLANVM MRSELIERIF RDRGAEDGFQ EIKNLRQNVR NALYEVRRII 240
 YDLRPMALDD LGLIPTLRKY LYTTEEYNGK VKIHFQCIGE TEDQRLAPQF EVALFRLAQE 300
 AVSNALKHSE SEEITVKVEI TKDFVILMIK DNGKGFDLKE AKEKKNKSFG LLGMKERVDL 360
 LEGTMTIDSK IGLGTFIMIK VPLSL 385
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0016021   C:integral component of membrane IEA:InterPro
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0004721   F:phosphoprotein phosphatase activity IEA:UniProtKB-KW
  GO:0000155   F:phosphorelay sensor kinase activity IEA:InterPro
  IPR008595   DegS.
  IPR003594   HATPase_ATP-bd.
  IPR011712   Sig_transdc_His_kin_sub3_dim/P.
  IPR005467   Sig_transdc_His_kinase_core.
  IPR016381   Sig_transdc_His_kinase_DegS.
  PF05384   DegS.
  PF02518   HATPase_c.
  PF07730   HisKA_3.
  SM00387   HATPase_c.
  PS50109   HIS_KIN.