※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator Hpr
Protein Synonyms/Alias
 
Gene Name
 hpr
Gene Synonyms/Alias
 catA, scoC; OrderedLocusNames=BSU09990
Created Date
 3-June-2014
Organism
 Bacillus subtilis (strain 168)
NCBI Taxa ID
 224308
Phosphorylation
Position
Peptide
Code
Type
References
3 *****MNRVEPPYDV R HTP [1]
Reference
 [1]Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis.
 Elsholz AK,Turgay K,Michalik S,Hessling B,Gronau K,Oertel D,Mäder U,Bernhardt J,Becher D,Hecker M,Gerth U
 Proc. Natl. Acad. Sci. U.S.A. 2012, May, 8;109(19):7451-6. [PMID:22517742]
Functional Description From UniProt
 FUNCTION: Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Directproteinsequencing; DNA-binding; Referenceproteome; Repressor; Sporulation; Transcription; Transcriptionregulation
Protein Sequence
 MNRVEPPYDV KEALVFTQKM AQLSKALWKS IEKDWQQWLK PYDLNINEHH ILWIAYQLNG 60
 ASISEIAKFG VMHVSTAFNF SKKLEERGYL RFSKRLNDKR NTYVQLTEEG TEVFWSLLEE 120
 FDPTRNAVFK GSQPLYHLFG KFPEVAEMMC MIRHIYGDDF MEIFETSLTN IDNDFESVNG 180
 KLKKKAKDSA ADEPAEELEP VNS 203
  GO:0005622   C:intracellular IEA:InterPro
  GO:0003677   F:DNA binding IEA:UniProtKB-HAMAP
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:UniProtKB-HAMAP
  GO:0045892   P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP
  GO:0006355   P:regulation of transcription, DNA-templated IMP:CACAO
  GO:0030435   P:sporulation resulting in formation of a cellular spore IEA:UniProtKB-HAMAP
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR000835   HTH_MarR-typ.
  IPR023488   HTH_tscrpt_reg_Hpr.
  IPR023187   Tscrpt_reg_MarR-type_CS.
  IPR011991   WHTH_DNA-bd_dom.
  PF01047   MarR.
  SM00347   HTH_MARR.
  PS01117   HTH_MARR_1.
  PS50995   HTH_MARR_2.