| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proline/betaine transporter |
Protein Synonyms/Alias | PPII |
Gene Name | proP |
Gene Synonyms/Alias | b4111, JW4072 |
Created Date | 3-June-2014 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Phosphorylation | Position | Peptide | Code | Type | References | | 454 | KGATPAASDIQEAKE | S | HTP | [1] | |
Reference | [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium. Soares NC,Spät P,Krug K,Macek B J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [ PMID:23590516] |
Functional Description From UniProt | FUNCTION: Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response |
| TRANSMEM 38 58 Helical; Name=1; (Potential)
TRANSMEM 66 86 Helical; Name=2; (Potential)
TRANSMEM 98 118 Helical; Name=3; (Potential)
TRANSMEM 122 142 Helical; Name=4; (Potential)
TRANSMEM 170 190 Helical; Name=5; (Potential)
TRANSMEM 195 215 Helical; Name=6; (Potential)
TRANSMEM 261 281 Helical; Name=7; (Potential)
TRANSMEM 298 318 Helical; Name=8; (Potential)
TRANSMEM 326 346 Helical; Name=9; (Potential)
TRANSMEM 351 371 Helical; Name=10; (Potential)
TRANSMEM 391 411 Helical; Name=11; (Potential)
TRANSMEM 417 437 Helical; Name=12; (Potential)
COILED 453 498 Potential |
| 3D-structure; Cellinnermembrane; Cellmembrane; Coiledcoil; Completeproteome; Membrane; Referenceproteome; Symport; Transmembrane; Transmembranehelix; Transport |
Protein Sequence | MLKRKKVKPI TLRDVTIIDD GKLRKAITAA SLGNAMEWFD FGVYGFVAYA LGKVFFPGAD 60
PSVQMVAALA TFSVPFLIRP LGGLFFGMLG DKYGRQKILA ITIVIMSIST FCIGLIPSYD 120
TIGIWAPILL LICKMAQGFS VGGEYTGASI FVAEYSPDRK RGFMGSWLDF GSIAGFVLGA 180
GVVVLISTIV GEANFLDWGW RIPFFIALPL GIIGLYLRHA LEETPAFQQH VDKLEQGDRE 240
GLQDGPKVSF KEIATKYWRS LLTCIGLVIA TNVTYYMLLT YMPSYLSHNL HYSEDHGVLI 300
IIAIMIGMLF VQPVMGLLSD RFGRRPFVLL GSVALFVLAI PAFILINSNV IGLIFAGLLM 360
LAVILNCFTG VMASTLPAMF PTHIRYSALA AAFNISVLVA GLTPTLAAWL VESSQNLMMP 420
AYYLMVVAVV GLITGVTMKE TANRPLKGAT PAASDIQEAK EILVEHYDNI EQKIDDIDHE 480
IADLQAKRTR LVQQHPRIDE 500 |
| GO:0016021 C:integral component of membrane IDA:EcoliWiki GO:0005887 C:integral component of plasma membrane IDA:EcoCyc GO:0005886 C:plasma membrane IDA:EcoliWiki GO:0015653 F:glycine betaine:hydrogen symporter activity IDA:EcoCyc GO:0005297 F:hydrogen:proline symporter activity IGI:EcoCyc GO:0006865 P:amino acid transport IDA:EcoliWiki GO:0031460 P:glycine betaine transport IDA:GOC GO:0042538 P:hyperosmotic salinity response IGI:EcoCyc GO:0035524 P:proline transmembrane transport IGI:GOC GO:0015824 P:proline transport IGI:EcoCyc |
| |
| |
| |
| |
| |
