※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sensory/regulatory protein RpfC
Protein Synonyms/Alias
 
Gene Name
 rpfC
Gene Synonyms/Alias
 XCC1856
Created Date
 3-June-2014
Organism
 Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
NCBI Taxa ID
 190485
Phosphorylation
Position
Peptide
Code
Type
References
657 EQLRESAHALRGVAS H LTP [1]
512 DYDAVIVDLHMPGMN D LTP [1]
198 RFLANMSHEFRTPLN H LTP [1]
Reference
 [1]Dual signaling functions of the hybrid sensor kinase RpfC of Xanthomonas campestris involve either phosphorelay or receiver domain-protein interaction.
 He YW,Wang C,Zhou L,Song H,Dow JM,Zhang LH
 J. Biol. Chem. 2006, Nov, 3;281(44):33414-21. [PMID:16940295]
Functional Description From UniProt
 FUNCTION: Member of the two-component regulatory system RpfG/RpfC, which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF), which is essential for cell- cell signaling. RpfC is probably a sensor of environmental signals, including DSF, which is autophosphorylated at a histidine residue in response to the signal. Then, probably activates RpfG via a four-step phosphorelay. May also negatively regulate the production of DSF, independently of RpfG (By similarity)
Sequence Annotation From UniProt
 TRANSMEM 23 40 Helical; (Potential)
 TRANSMEM 52 72 Helical; (Potential)
 TRANSMEM 95 115 Helical; (Potential)
 TRANSMEM 128 148 Helical; (Potential)
 TRANSMEM 152 172 Helical; (Potential)
 MOD_RES 198 198 Phosphohistidine; by autocatalysis (By similarity)
 MOD_RES 512 512 4-aspartylphosphate (By similarity)
 MOD_RES 657 657 Phosphohistidine (By similarity)
Key Word From UniProt
 3D-structure; ATP-binding; Cellinnermembrane; Cellmembrane; Completeproteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Referenceproteome; Transcription; Transcriptionregulation; Transferase; Transmembrane; Transmembranehelix; Two-componentregulatorysystem; Virulence
Protein Sequence
 MKSPLPWLKR RLSGRADSEH AQNLIRIIIT TLFISYLGWR YQHTHGDTLM ATWLILVGEL 60
 LVSLGLMVAI LLRPQVSHTR RLIGMLLDYT CTGAIMAIQG EPASPLYAVC MWVTIGNGLR 120
 YGSNYLRAAT AMGSLCFLGA ILISPYWKAN PYLSWGLLLG LIAVPLYFDS LLRAMTRAVR 180
 EARHANQAKS RFLANMSHEF RTPLNGLSGM TEVLATTRLD AEQKECLNTI QASARSLLSL 240
 VEEVLDISAI EAGKIRIDRR DFSLREMIGS VNLILQPQAR GRRLEYGTQV ADDVPDLLKG 300
 DTAHLRQVLL NLVGNAVKFT EHGHVLLRVT RVSGSAEDAV RLRFDVEDTG IGVPMDMRPR 360
 LFEAFEQADV GLSRRYEGTG LGTTIAKGLV EAMGGSIGFK ENQPSGSVFW FELPMAIGEP 420
 LKSSTVRVPT GALVDAPEEL ESSNIIAFSN PFLRHRARVR SMRMLVADDH EANRMVLQRL 480
 LEKAGHKVLC VNGAEQVLDA MAEEDYDAVI VDLHMPGMNG LDMLKQLRVM QASGMRYTPV 540
 VVLSADVTPE AIRACEQAGA RAFLAKPVVA AKLLDTLADL AVSTRQLATP ATTVQVATSF 600
 EGVLDSSVLD ELAALGMGEE FERQFVRQCL DDAQNCVGDI ERDGTCSDWE QLRESAHALR 660
 GVASNLGLAQ VASSGGELMR MADWQLQAEW RLRLSTLREQ LKAGKDALDA RVQGVKDGEC 720
 SPRSNE 726
  GO:0016021   C:integral component of membrane IEA:UniProtKB-KW
  GO:0005886   C:plasma membrane IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0000155   F:phosphorelay sensor kinase activity IEA:InterPro
  GO:0009405   P:pathogenesis IEA:UniProtKB-KW
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR011006   CheY-like_superfamily.
  IPR003661   EnvZ-like_dim/P.
  IPR003594   HATPase_ATP-bd.
  IPR004358   Sig_transdc_His_kin-like_C.
  IPR008207   Sig_transdc_His_kin_Hpt_dom.
  IPR005467   Sig_transdc_His_kinase_core.
  IPR009082   Sig_transdc_His_kinase_dimeric.
  IPR001789   Sig_transdc_resp-reg_receiver.
  PF02518   HATPase_c.
  PF00512   HisKA.
  PF01627   Hpt.
  PF00072   Response_reg.
  SM00387   HATPase_c.
  SM00388   HisKA.
  SM00073   HPT.
  SM00448   REC.
  PS50109   HIS_KIN.
  PS50894   HPT.
  PS50110   RESPONSE_REGULATORY.
  PR00344   BCTRLSENSOR.