※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein translocase subunit SecY
Protein Synonyms/Alias
 
Gene Name
 secY
Gene Synonyms/Alias
 Z4670, ECs4165
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
258 RQQGRRVYAAQSTHL Y HTP [1]
441 KKANLKGYGRMAKQP Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Sequence Annotation From UniProt
 TRANSMEM 24 44 Helical; (Potential)
 TRANSMEM 77 97 Helical; (Potential)
 TRANSMEM 125 145 Helical; (Potential)
 TRANSMEM 154 174 Helical; (Potential)
 TRANSMEM 183 203 Helical; (Potential)
 TRANSMEM 217 237 Helical; (Potential)
 TRANSMEM 274 294 Helical; (Potential)
 TRANSMEM 317 337 Helical; (Potential)
 TRANSMEM 370 390 Helical; (Potential)
 TRANSMEM 397 417 Helical; (Potential)
Key Word From UniProt
 Cellinnermembrane; Cellmembrane; Completeproteome; Membrane; Proteintransport; Translocation; Transmembrane; Transmembranehelix; Transport
Protein Sequence
 MAKQPGLDFQ SAKGGLGELK RRLLFVIGAL IVFRIGSFIP IPGIDAAVLA KLLEQQRGTI 60
 IEMFNMFSGG ALSRASIFAL GIMPYISASI IIQLLTVVHP TLAEIKKEGE SGRRKISQYT 120
 RYGTLVLAIF QSIGIATGLP NMPGMQGLVI NPGFAFYFTA VVSLVTGTMF LMWLGEQITE 180
 RGIGNGISII IFAGIVAGLP PAIAHTIEQA RQGDLHFLVL LLVAVLVFAV TFFVVFVERG 240
 QRRIVVNYAK RQQGRRVYAA QSTHLPLKVN MAGVIPAIFA SSIILFPATI ASWFGGGTGW 300
 NWLTTISLYL QPGQPLYVLL YASAIIFFCF FYTALVFNPR ETADNLKKSG AFVPGIRPGE 360
 QTAKYIDKVM TRLTLVGALY ITFICLIPEF MRDAMKVPFY FGGTSLLIVV VVIMDFMAQV 420
 QTLMMSSQYE SALKKANLKG YGR 443
  GO:0016021   C:integral component of membrane IEA:UniProtKB-KW
  GO:0005622   C:intracellular IEA:GOC
  GO:0005886   C:plasma membrane IEA:UniProtKB-SubCell
  GO:0065002   P:intracellular protein transmembrane transport IEA:UniProtKB-HAMAP
  GO:0006605   P:protein targeting IEA:UniProtKB-HAMAP
  GO:0043952   P:protein transport by the Sec complex IEA:UniProtKB-HAMAP
  IPR026593   SecY.
  IPR002208   SecY/SEC61-alpha.
  IPR023201   SecY_su_dom.
  PF00344   SecY.
  PS00755   SECY_1.
  PS00756   SECY_2.