※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein translocase subunit SecY
Protein Synonyms/Alias
 
Gene Name
 secY
Gene Synonyms/Alias
 prlA; OrderedLocusNames=b3300, JW3262
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
11 QPGLDFQSAKGGLGE S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY
Sequence Annotation From UniProt
 TRANSMEM 23 35 Helical; Name=1; (Probable)
 TRANSMEM 61 96 Discontinuously helical; Name=2; (By similarity)
 TRANSMEM 116 131 Helical; Name=3; (Probable)
 TRANSMEM 165 178 Helical; Name=4; (Probable)
 TRANSMEM 184 200 Helical; Name=5; (Probable)
 TRANSMEM 224 237 Helical; Name=6; (Probable)
 TRANSMEM 274 287 Helical; Name=7; (Probable)
 TRANSMEM 314 329 Helical; Name=8; (Probable)
 TRANSMEM 381 395 Helical; Name=9; (Probable)
 TRANSMEM 397 413 Helical; Name=10; (Probable)
Key Word From UniProt
 3D-structure; Cellinnermembrane; Cellmembrane; Completeproteome; Membrane; Proteintransport; Referenceproteome; Translocation; Transmembrane; Transmembranehelix; Transport
Protein Sequence
 MAKQPGLDFQ SAKGGLGELK RRLLFVIGAL IVFRIGSFIP IPGIDAAVLA KLLEQQRGTI 60
 IEMFNMFSGG ALSRASIFAL GIMPYISASI IIQLLTVVHP TLAEIKKEGE SGRRKISQYT 120
 RYGTLVLAIF QSIGIATGLP NMPGMQGLVI NPGFAFYFTA VVSLVTGTMF LMWLGEQITE 180
 RGIGNGISII IFAGIVAGLP PAIAHTIEQA RQGDLHFLVL LLVAVLVFAV TFFVVFVERG 240
 QRRIVVNYAK RQQGRRVYAA QSTHLPLKVN MAGVIPAIFA SSIILFPATI ASWFGGGTGW 300
 NWLTTISLYL QPGQPLYVLL YASAIIFFCF FYTALVFNPR ETADNLKKSG AFVPGIRPGE 360
 QTAKYIDKVM TRLTLVGALY ITFICLIPEF MRDAMKVPFY FGGTSLLIVV VVIMDFMAQV 420
 QTLMMSSQYE SALKKANLKG YGR 443
  GO:0016021   C:integral component of membrane IDA:EcoliWiki
  GO:0005887   C:integral component of plasma membrane IDA:EcoCyc
  GO:0005622   C:intracellular IMP:GOC
  GO:0005886   C:plasma membrane IDA:EcoliWiki
  GO:0065002   P:intracellular protein transmembrane transport IMP:EcoliWiki
  GO:0006886   P:intracellular protein transport IMP:EcoliWiki
  GO:0006605   P:protein targeting IEA:UniProtKB-HAMAP
  GO:0043952   P:protein transport by the Sec complex IDA:EcoCyc
  IPR026593   SecY.
  IPR002208   SecY/SEC61-alpha.
  IPR023201   SecY_su_dom.
  PF00344   SecY.
  PS00755   SECY_1.
  PS00756   SECY_2.