UniProt Accession

 NUOI_ECO57;  P0AFD8;  P33604;  P76488;  P78183

Genbank Protein ID

 AE005174;  BA000007

Genbank Nucleotide ID

 AAG57410.1;  BAB36588.1

Protein Name

 NADH-quinone oxidoreductase subunit I

Protein Synonyms/Alias

 

Gene Name

 nuoI

Gene Synonyms/Alias

 Z3540, ECs3165

Created Date

 3-June-2014

Organism

 Escherichia coli O157:H7

NCBI Taxa ID

 83334

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 4Fe-4S; Cellinnermembrane; Cellmembrane; Completeproteome; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Repeat; Ubiquinone

Protein Sequence

  GO:0005886   C:plasma membrane IEA:UniProtKB-SubCell
  GO:0051539   F:4 iron, 4 sulfur cluster binding IEA:UniProtKB-KW
  GO:0005506   F:iron ion binding IEA:UniProtKB-HAMAP
  GO:0050136   F:NADH dehydrogenase (quinone) activity IEA:UniProtKB-HAMAP
  GO:0048038   F:quinone binding IEA:UniProtKB-KW

  IPR001450   4Fe4S-bd_dom.
  IPR017896   4Fe4S_Fe-S-bd.
  IPR017900   4Fe4S_Fe_S_CS.
  IPR010226   NADH_quinone_OxRdtase_chainI.

  PF00037   Fer4.

  PS00198   4FE4S_FER_1.
  PS51379   4FE4S_FER_2.