| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nitrate/nitrite sensor protein NarX |
Protein Synonyms/Alias | |
Gene Name | narX |
Gene Synonyms/Alias | Z1998, ECs1727 |
Created Date | 3-June-2014 |
Organism | Escherichia coli O157:H7 |
NCBI Taxa ID | 83334 |
Phosphorylation | Position | Peptide | Code | Type | References | | 58 | GSLRMQSYRLLAAVP | Y | HTP | [1] | |
Reference | [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A PLoS Pathog. 2013;9(6):e1003403. [ PMID:23785281] |
Functional Description From UniProt | FUNCTION: Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate/nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate (By similarity) |
| TRANSMEM 15 37 Helical; (Potential)
TRANSMEM 152 174 Helical; (Potential)
MOD_RES 399 399 Phosphohistidine; by autocatalysis (By similarity) |
| ATP-binding; Cellinnermembrane; Cellmembrane; Completeproteome; Kinase; Membrane; Nitrateassimilation; Nucleotide-binding; Phosphoprotein; Transferase; Transmembrane; Transmembranehelix; Two-componentregulatorysystem |
Protein Sequence | MLKRCLSPLT LVNQVALIVL LSTAIGLAGM AVSGWLVQGV QGSAHAINKA GSLRMQSYRL 60
LAAVPLSEKD KPLIKEMEQT AFSAELTRAA ERDGQLAQLQ GLQDYWRNEL IPALMRAQNR 120
ETVSADVSQF VAGLDQLVSG FDRTTEMRIE TVVLVHRVMA VFMALLLVFT IIWLRARLLQ 180
PWRQLLAMAS AVSHRDFTQR ANISGRNEMA MLGTALNNMS AELAESYAVL EQRVQEKTAG 240
LEHKNQILSF LWQANRRLHS RAPLCERLSP VLNGLQNLTL LRDIELRVYD TDDEENHQEF 300
TCQPDMTCDD KGCQLCPRGV LPVGDRGTTL KWRLADSHTQ YGILLATLPQ GRHLSHDQQQ 360
LVDTLVEQLT ATLALDRHQE RQQQLIVMEE RATIARELHD SIAQSLSCMK MQVSCLQMQG 420
DALPESSREL LSQIRNELNA SWAQLRELLT TFRLQLTEPG LRPALEASCE EYSAKFGFPV 480
KLDYQLPPRL VPSHQAIHLL QIAREALSNA LKHSQASEVV VTVAQNDNQV KLTVQDNGCG 540
VPENAIRSNH YGMIIMRDRA QSLRGDCRVR RRESGGTEVV VTFIPEKTFT DVQGDTHE 598 |
| GO:0016021 C:integral component of membrane IEA:UniProtKB-KW GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell GO:0005524 F:ATP binding IEA:UniProtKB-KW GO:0000155 F:phosphorelay sensor kinase activity IEA:InterPro GO:0042128 P:nitrate assimilation IEA:UniProtKB-KW |
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