※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 7-alpha-hydroxysteroid dehydrogenase
Protein Synonyms/Alias
 7-alpha-HSDH
Gene Name
 hdhA
Gene Synonyms/Alias
 hsdH; OrderedLocusNames=b1619, JW1611
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
199 ILTDALKSVITPEIE S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Bileacidcatabolism; Completeproteome; Directproteinsequencing; Lipiddegradation; Lipidmetabolism; NAD; Oxidoreductase; Referenceproteome; Steroidmetabolism
Protein Sequence
 MFNSDNLRLD GKCAIITGAG AGIGKEIAIT FATAGASVVV SDINADAANH VVDEIQQLGG 60
 QAFACRCDIT SEQELSALAD FAISKLGKVD ILVNNAGGGG PKPFDMPMAD FRRAYELNVF 120
 SFFHLSQLVA PEMEKNGGGV ILTITSMAAE NKNINMTSYA SSKAAASHLV RNMAFDLGEK 180
 NIRVNGIAPG AILTDALKSV ITPEIEQKML QHTPIRRLGQ PQDIANAALF LCSPAASWVS 240
 GQILTVSGGG VQELN 255
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0008709   F:cholate 7-alpha-dehydrogenase activity IDA:EcoCyc
  GO:0030573   P:bile acid catabolic process IEA:UniProtKB-KW
  IPR002198   DH_sc/Rdtase_SDR.
  IPR002347   Glc/ribitol_DH.
  IPR016040   NAD(P)-bd_dom.
  IPR020904   Sc_DH/Rdtase_CS.
  PF00106   adh_short.
  PS00061   ADH_SHORT.
  PR00081   GDHRDH.
  PR00080   SDRFAMILY.