※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Osmolarity sensor protein EnvZ
Protein Synonyms/Alias
 
Gene Name
 envZ
Gene Synonyms/Alias
 ompB, perA, tpo; OrderedLocusNames=b3404, JW3367
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
243 LLMAGVSHDLRTPLT H LTP [1],UniProt
Reference
 [1]Identification of the site of phosphorylation on the osmosensor, EnvZ, of Escherichia coli.
 Roberts DL,Bennett DW,Forst SA
 J. Biol. Chem. 1994, Mar, 25;269(12):8728-33. [PMID:8132603]
Functional Description From UniProt
 FUNCTION: Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals
Sequence Annotation From UniProt
 TRANSMEM 16 35 Helical; (Probable)
 TRANSMEM 159 179 Helical; (Probable)
 MOD_RES 243 243 Phosphohistidine; by autocatalysis
Key Word From UniProt
 3D-structure; ATP-binding; Cellinnermembrane; Cellmembrane; Completeproteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Referenceproteome; Transferase; Transmembrane; Transmembranehelix; Two-componentregulatorysystem
Protein Sequence
 MRRLRFSPRS SFARTLLLIV TLLFASLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD 60
 KLQLEDGTQL VVPPAFRREI YRELGISLYS NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT 120
 EVRVEVNKSS PVVWLKTWLS PNIWVRVPLT EIHQGDFSPL FRYTLAIMLL AIGGAWLFIR 180
 IQNRPLVDLE HAALQVGKGI IPPPLREYGA SEVRSVTRAF NHMAAGVKQL ADDRTLLMAG 240
 VSHDLRTPLT RIRLATEMMS EQDGYLAESI NKDIEECNAI IEQFIDYLRT GQEMPMEMAD 300
 LNAVLGEVIA AESGYEREIE TALYPGSIEV KMHPLSIKRA VANMVVNAAR YGNGWIKVSS 360
 GTEPNRAWFQ VEDDGPGIAP EQRKHLFQPF VRGDSARTIS GTGLGLAIVQ RIVDNHNGML 420
 ELGTSERGGL SIRAWLPVPV TRAQGTTKEG 450
  GO:0009898   C:cytoplasmic side of plasma membrane IDA:EcoCyc
  GO:0005887   C:integral component of plasma membrane IDA:EcoCyc
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0004721   F:phosphoprotein phosphatase activity IDA:EcoCyc
  GO:0000155   F:phosphorelay sensor kinase activity IMP:EcoCyc
  GO:0071229   P:cellular response to acid IMP:EcoliWiki
  GO:0016048   P:detection of temperature stimulus IGI:EcoliWiki
  GO:0000160   P:phosphorelay signal transduction system IDA:EcoliWiki
  GO:0016310   P:phosphorylation IDA:EcoliWiki
  GO:0046777   P:protein autophosphorylation IMP:CACAO
  GO:0006470   P:protein dephosphorylation IDA:EcoliWiki
  GO:0047484   P:regulation of response to osmotic stress IMP:EcoCyc
  GO:0023014   P:signal transduction by phosphorylation IMP:GOC
  IPR003661   EnvZ-like_dim/P.
  IPR003660   HAMP_linker_domain.
  IPR003594   HATPase_ATP-bd.
  IPR004358   Sig_transdc_His_kin-like_C.
  IPR005467   Sig_transdc_His_kinase_core.
  IPR009082   Sig_transdc_His_kinase_dimeric.
  PF00672   HAMP.
  PF02518   HATPase_c.
  PF00512   HisKA.
  SM00304   HAMP.
  SM00387   HATPase_c.
  SM00388   HisKA.
  PS50885   HAMP.
  PS50109   HIS_KIN.
  PR00344   BCTRLSENSOR.