Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aerobic respiration control sensor protein ArcB |
Protein Synonyms/Alias | |
Gene Name | arcB |
Gene Synonyms/Alias | b3210, JW5536 |
Created Date | 3-June-2014 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Phosphorylation | Position | Peptide | Code | Type | References | 576 | EYDLVLLDIQLPDMT | D | LTP | [1] | 292 | TFISTISHELRTPLN | H | LTP | [1],UniProt | 717 | KGIVEEGHKIKGAAG | H | LTP | [1] | |
Reference | [1]Amplification of signaling activity of the arc two-component system of Escherichia coli by anaerobic metabolites. An in vitro study with different protein modules. Georgellis D,Kwon O,Lin EC J. Biol. Chem. 1999, Dec, 10;274(50):35950-4. [ PMID:10585483] |
Functional Description From UniProt | FUNCTION: Member of the two-component regulatory system ArcB/ArcA Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 |
| TRANSMEM 26 46 Helical; (Potential) TRANSMEM 58 78 Helical; (Potential) MOD_RES 292 292 Phosphohistidine; by autocatalysis MOD_RES 576 576 4-aspartylphosphate (Probable) MOD_RES 717 717 Phosphohistidine (Probable) |
| 3D-structure; ATP-binding; Cellinnermembrane; Cellmembrane; Completeproteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Referenceproteome; Transcription; Transcriptionregulation; Transferase; Transmembrane; Transmembranehelix; Two-componentregulatorysystem |
Protein Sequence | MKQIRLLAQY YVDLMMKLGL VRFSMLLALA LVVLAIVVQM AVTMVLHGQV ESIDVIRSIF 60 FGLLITPWAV YFLSVVVEQL EESRQRLSRL VQKLEEMRER DLSLNVQLKD NIAQLNQEIA 120 VREKAEAELQ ETFGQLKIEI KEREETQIQL EQQSSFLRSF LDASPDLVFY RNEDKEFSGC 180 NRAMELLTGK SEKQLVHLKP ADVYSPEAAA KVIETDEKVF RHNVSLTYEQ WLDYPDGRKA 240 CFEIRKVPYY DRVGKRHGLM GFGRDITERK RYQDALERAS RDKTTFISTI SHELRTPLNG 300 IVGLSRILLD TELTAEQEKY LKTIHVSAVT LGNIFNDIID MDKMERRKVQ LDNQPVDFTS 360 FLADLENLSA LQAQQKGLRF NLEPTLPLPH QVITDGTRLR QILWNLISNA VKFTQQGQVT 420 VRVRYDEGDM LHFEVEDSGI GIPQDELDKI FAMYYQVKDS HGGKPATGTG IGLAVSRRLA 480 KNMGGDITVT SEQGKGSTFT LTIHAPSVAE EVDDAFDEDD MPLPALNVLL VEDIELNVIV 540 ARSVLEKLGN SVDVAMTGKA ALEMFKPGEY DLVLLDIQLP DMTGLDISRE LTKRYPREDL 600 PPLVALTANV LKDKQEYLNA GMDDVLSKPL SVPALTAMIK KFWDTQDDEE STVTTEENSK 660 SEALLDIPML EQYLELVGPK LITDGLAVFE KMMPGYVSVL ESNLTAQDKK GIVEEGHKIK 720 GAAGSVGLRH LQQLGQQIQS PDLPAWEDNV GEWIEEMKEE WRHDVEVLKA WVAKATKK 778 |
| GO:0016021 C:integral component of membrane IDA:EcoCyc GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell GO:0005524 F:ATP binding IEA:UniProtKB-KW GO:0009927 F:histidine phosphotransfer kinase activity IDA:EcoCyc GO:0000156 F:phosphorelay response regulator activity IEA:InterPro GO:0000155 F:phosphorelay sensor kinase activity IDA:EcoCyc GO:0000160 P:phosphorelay signal transduction system IDA:EcoCyc GO:0046777 P:protein autophosphorylation IMP:CACAO GO:0006355 P:regulation of transcription, DNA-templated IEA:UniProtKB-KW GO:0023014 P:signal transduction by phosphorylation IDA:GOC GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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