※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 D-alanyl-D-alanine carboxypeptidase DacA
Protein Synonyms/Alias
 DD-carboxypeptidase;  DD-peptidase;  PBP-5
Gene Name
 dacA
Gene Synonyms/Alias
 pfv; OrderedLocusNames=b0632, JW0627
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
345 KASYVLNSSELHAPL S HTP [1]
6 **MNTIFSARIMKRL S HTP [2]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Carboxypeptidase; Cellinnermembrane; Cellmembrane; Cellshape; Cellwallbiogenesis/degradation; Completeproteome; Directproteinsequencing; Hydrolase; Membrane; Peptidoglycansynthesis; Protease; Referenceproteome; Signal
Protein Sequence
 MNTIFSARIM KRLALTTALC TAFISAAHAD DLNIKTMIPG VPQIDAESYI LIDYNSGKVL 60
 AEQNADVRRD PASLTKMMTS YVIGQAMKAG KFKETDLVTI GNDAWATGNP VFKGSSLMFL 120
 KPGMQVPVSQ LIRGINLQSG NDACVAMADF AAGSQDAFVG LMNSYVNALG LKNTHFQTVH 180
 GLDADGQYSS ARDMALIGQA LIRDVPNEYS IYKEKEFTFN GIRQLNRNGL LWDNSLNVDG 240
 IKTGHTDKAG YNLVASATEG QMRLISAVMG GRTFKGREAE SKKLLTWGFR FFETVNPLKV 300
 GKEFASEPVW FGDSDRASLG VDKDVYLTIP RGRMKDLKAS YVLNSSELHA PLQKNQVVGT 360
 INFQLDGKTI EQRPLVVLQE IPEGNFFGKI IDYIKLMFHH WFG 403
  GO:0005887   C:integral component of plasma membrane IDA:EcoliWiki
  GO:0008800   F:beta-lactamase activity IEA:UniProtKB-EC
  GO:0004180   F:carboxypeptidase activity IDA:EcoCyc
  GO:0008658   F:penicillin binding IDA:EcoCyc
  GO:0009002   F:serine-type D-Ala-D-Ala carboxypeptidase activity IDA:CACAO
  GO:0051301   P:cell division IGI:EcoCyc
  GO:0044036   P:cell wall macromolecule metabolic process IDA:EcoCyc
  GO:0009252   P:peptidoglycan biosynthetic process IEA:UniProtKB-UniPathway
  GO:0000270   P:peptidoglycan metabolic process IDA:EcoCyc
  GO:0008360   P:regulation of cell shape IGI:EcoCyc
  IPR012338   Beta-lactam/transpept-like.
  IPR015956   Peniciliin-bd_prot-assoc.
  IPR018044   Peptidase_S11.
  IPR012907   Peptidase_S11_C.
  IPR001967   Peptidase_S11_N.
  PF07943   PBP5_C.
  PF00768   Peptidase_S11.
  SM00936   PBP5_C.
  PR00725   DADACBPTASE1.