UniProt Accession

 CHEY_ECOLI;  P0AE67;  P06143

Genbank Protein ID

 K02175;  M13463;  U00096;  AP009048

Genbank Nucleotide ID

 AAA23577.1;  AAA23570.1;  AAC74952.1;  BAA15698.1

Protein Name

 Chemotaxis protein CheY

Protein Synonyms/Alias

 

Gene Name

 cheY

Gene Synonyms/Alias

 b1882, JW1871

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Crystal structure of Escherichia coli CheY refined at 1.7-A resolution.
 Volz K,Matsumura P
 J. Biol. Chem. 1991, Aug, 15;266(23):15511-9. [PMID:1869568]
 [2]Identification of the site of phosphorylation of the chemotaxis response regulator protein, CheY.
 Sanders DA,Gillece-Castro BL,Stock AM,Burlingame AL,Koshland DE
 J. Biol. Chem. 1989, Dec, 25;264(36):21770-8. [PMID:2689446]

Functional Description From UniProt

 FUNCTION: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation. Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein and the flagellar stator

Sequence Annotation From UniProt

 MOD_RES 57 57 4-aspartylphosphate
 MOD_RES 92 92 N6-acetyllysine
 MOD_RES 109 109 N6-acetyllysine

Key Word From UniProt

 3D-structure; Acetylation; Chemotaxis; Completeproteome; Cytoplasm; Directproteinsequencing; Flagellarrotation; Magnesium; Metal-binding; Phosphoprotein; Referenceproteome; Two-componentregulatorysystem

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0016407   F:acetyltransferase activity IDA:CACAO
  GO:0000287   F:magnesium ion binding IMP:EcoCyc
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0071973   P:bacterial-type flagellum-dependent cell motility TAS:EcoCyc
  GO:0006935   P:chemotaxis IMP:EcoCyc
  GO:0018393   P:internal peptidyl-lysine acetylation IMP:CACAO
  GO:0000160   P:phosphorelay signal transduction system IDA:EcoCyc
  GO:0006473   P:protein acetylation IDA:EcoCyc

  IPR011006   CheY-like_superfamily.
  IPR001789   Sig_transdc_resp-reg_receiver.

  PF00072   Response_reg.

  SM00448   REC.

  PS50110   RESPONSE_REGULATORY.