UniProt Accession

 MAP1_ECOLI;  P0AE18;  P07906

Genbank Protein ID

 M15106;  U70214;  U00096;  AP009048

Genbank Nucleotide ID

 AAA24112.1;  AAB08597.1;  AAC73279.1;  BAB96743.1

Protein Name

 Methionine aminopeptidase

Protein Synonyms/Alias

 MAP;  MetAP

Gene Name

 map

Gene Synonyms/Alias

 b0168, JW0163

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [2]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Removes the N-terminal methionine from nascent proteins The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Aminopeptidase; Completeproteome; Directproteinsequencing; Hydrolase; Metal-binding; Protease; Referenceproteome

Protein Sequence

  GO:0005829   C:cytosol IDA:EcoCyc
  GO:0008198   F:ferrous iron binding IDA:EcoCyc
  GO:0070006   F:metalloaminopeptidase activity IDA:EcoCyc
  GO:0070084   P:protein initiator methionine removal IDA:EcoCyc

  IPR001714   Pept_M24_MAP.
  IPR000994   Pept_M24_structural-domain.
  IPR002467   Pept_M24A_MAP1.

  PF00557   Peptidase_M24.

  PS00680   MAP_1.

  PR00599   MAPEPTIDASE.