UniProt Accession

 AHPC_ECOLI;  P0AE08;  P26427

Genbank Protein ID

 D13187;  U82598;  U00096;  AP009048

Genbank Nucleotide ID

 BAA02485.1;  AAB40806.1;  AAC73706.1;  BAA35235.1

Protein Name

 Alkyl hydroperoxide reductase subunit C

Protein Synonyms/Alias

 SSI8

Gene Name

 ahpC

Gene Synonyms/Alias

 b0605, JW0598

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [3]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Directly reduces organic hydroperoxides in its reduced dithiol form

Sequence Annotation From UniProt

 MOD_RES 17 17 N6-acetyllysine
 MOD_RES 93 93 N6-acetyllysine
 MOD_RES 153 153 N6-acetyllysine
 MOD_RES 169 169 N6-acetyllysine
 MOD_RES 171 171 N6-acetyllysine
 DISULFID 47 47 Interchain (with C-166); in linked form (By similarity)
 DISULFID 166 166 Interchain (with C-47); in linked form (By similarity)

Key Word From UniProt

 Acetylation; Antioxidant; Completeproteome; Directproteinsequencing; Disulfidebond; Oxidoreductase; Peroxidase; Redox-activecenter; Referenceproteome

Protein Sequence

  GO:0005737   C:cytoplasm IDA:EcoliWiki
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0032843   F:hydroperoxide reductase activity IDA:EcoliWiki
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0016684   F:oxidoreductase activity, acting on peroxide as acceptor IMP:EcoliWiki
  GO:0004601   F:peroxidase activity IGI:EcoliWiki
  GO:0051920   F:peroxiredoxin activity IEA:UniProtKB-EC
  GO:0009970   P:cellular response to sulfate starvation IDA:EcoliWiki
  GO:0033214   P:iron assimilation by chelation and transport IMP:CACAO
  GO:0033195   P:response to alkyl hydroperoxide IMP:EcoCyc
  GO:0033194   P:response to hydroperoxide IMP:EcoCyc

  IPR017559   AhpC.
  IPR000866   AhpC/TSA.
  IPR024706   Peroxiredoxin_AhpC-typ.
  IPR019479   Peroxiredoxin_C.
  IPR012336   Thioredoxin-like_fold.

  PF10417   1-cysPrx_C.
  PF00578   AhpC-TSA.

  PS51352   THIOREDOXIN_2.