※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inosine-5'-monophosphate dehydrogenase
Protein Synonyms/Alias
 IMP dehydrogenase;  IMPD;  IMPDH
Gene Name
 guaB
Gene Synonyms/Alias
 Z3772, ECs3370
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
402 SKGSSDRYFQSDNAA Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Sequence Annotation From UniProt
 MOD_RES 267 267 N6-acetyllysine (By similarity)
 MOD_RES 428 428 N6-acetyllysine (By similarity)
Key Word From UniProt
 Acetylation; CBSdomain; Completeproteome; GMPbiosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purinebiosynthesis; Repeat
Protein Sequence
 MLRIAKEALT FDDVLLVPAH STVLPNTADL STQLTKTIRL NIPMLSAAMD TVTEARLAIA 60
 LAQEGGIGFI HKNMSIERQA EEVRRVKKHE SGVVTDPQTV LPTTTLREVK ELTERNGFAG 120
 YPVVTEENEL VGIITGRDVR FVTDLNQPVS VYMTPKERLV TVREGEAREV VLAKMHEKRV 180
 EKALVVDDEF HLIGMITVKD FQKAERKPNA CKDEQGRLRV GAAVGAGAGN EERVDALVAA 240
 GVDVLLIDSS HGHSEGVLQR IRETRAKYPD LQIIGGNVAT AAGARALAEA GCSAVKVGIG 300
 PGSICTTRIV TGVGVPQITA VADAVEALEG TGIPVIADGG IRFSGDIAKA IAAGASAVMV 360
 GSMLAGTEES PGEIELYQGR SYKSYRGMGS LGAMSKGSSD RYFQSDNAAD KLVPEGIEGR 420
 VAYKGRLKEI IHQQMGGLRS CMGLTGCGTI DELRTKAEFV RISGAGIQES HVHDVTITKE 480
 SPNYRLGS 488
  GO:0030554   F:adenyl nucleotide binding IEA:InterPro
  GO:0003938   F:IMP dehydrogenase activity IEA:UniProtKB-HAMAP
  GO:0046872   F:metal ion binding IEA:UniProtKB-HAMAP
  GO:0006177   P:GMP biosynthetic process IEA:UniProtKB-HAMAP
  IPR013785   Aldolase_TIM.
  IPR000644   CBS_dom.
  IPR005990   IMP_DH.
  IPR015875   IMP_DH/GMP_Rdtase_CS.
  IPR001093   IMP_DH_GMPRt.
  PF00571   CBS.
  PF00478   IMPDH.
  SM00116   CBS.
  PS51371   CBS.
  PS00487   IMP_DH_GMP_RED.