※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional repressor PurR
Protein Synonyms/Alias
 
Gene Name
 purR
Gene Synonyms/Alias
 Z2681, ECs2367
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
339 ADGPFRDYRRMATIK Y HTP [1]
45 AAIKELHYSPSAVAR Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; DNA-binding; Purinebiosynthesis; Repressor; Transcription; Transcriptionregulation
Protein Sequence
 MATIKDVAKR ANVSTTTVSH VINKTRFVAE ETRNAVWAAI KELHYSPSAV ARSLKVNHTK 60
 SIGLLATSSE AAYFAEIIEA VEKNCFQKGY TLILGNAWNN LEKQRAYLSM MAQKRVDGLL 120
 VMCSEYPEPL LAMLEEYRHI PMVVMDWGEA KADFTDAVID NAFEGGYMAG RYLIERGHRE 180
 IGVIPGPLER NTGAGRLAGF MKAMEEAMIK VPESWIVQGD FEPESGYRAM QQILSQPHRP 240
 TAVFCGGDIM AMGALCAADE MGLRVPQDVS LIGYDNVRNA RYFTPALTTI HQPKDSLGET 300
 AFNMLLDRIV NKREEPQSIE VHPRLIERRS VADGPFRDYR R 341
  GO:0003677   F:DNA binding IEA:UniProtKB-HAMAP
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0045892   P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP
  GO:0006164   P:purine nucleotide biosynthetic process IEA:UniProtKB-UniPathway
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR010982   Lambda_DNA-bd_dom.
  IPR028082   Peripla_BP_I.
  IPR000843   Tscrpt_reg_HTH_LacI.
  IPR023588   Tscrpt_reg_HTH_PurR.
  PF00356   LacI.
  SM00354   HTH_LACI.
  PS00356   HTH_LACI_1.
  PS50932   HTH_LACI_2.
  PR00036   HTHLACI.