※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-binding protein H-NS
Protein Synonyms/Alias
 
Gene Name
 hns
Gene Synonyms/Alias
 Z2013, ECs1739
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
99 QRPAKYSYVDENGET Y HTP [1]
61 RTRKLQQYREMLIAD Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. It plays a role in the thermal control of pili production. It is subject to transcriptional auto-repression. It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; DNA-binding; Repressor; Transcription; Transcriptionregulation
Protein Sequence
 MSEALKILNN IRTLRAQARE CTLETLEEML EKLEVVVNER REEESAAAAE VEERTRKLQQ 60
 YREMLIADGI DPNELLNSLA AVKSGTKAKR AQRPAKYSYV DENGETKTWT GQGRTPAVIK 120
 KAMDEQGKSL DDFLIKQ 137
  GO:0005622   C:intracellular IEA:InterPro
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR027444   H-NS_C_dom.
  IPR001801   Histone_HNS.
  IPR027454   Histone_HNS_oligo_dom.
  PF00816   Histone_HNS.
  SM00528   HNS.