※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-binding protein H-NS
Protein Synonyms/Alias
 
Gene Name
 hns
Gene Synonyms/Alias
 bglY, cur, drdX, hnsA, msyA, osmZ, pilG, topS
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
78 DPNELLNSLAAVKSG S HTP [1]
61 RTRKLQQYREMLIAD Y HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: A DNA-binding protein implicated in transcriptional repression (silencing) as well as in bacterial chromosome organization. H-NS binds tightly to AT-rich dsDNA, increases its thermal stability and inhibits transcription. Also binds to ssDNA and RNA but with a much lower affinity. H-NS has possible histone- like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. Plays a role in the thermal control of pili and adhesive curli fimbriae production, by inducing transcription of csgD. Represses the CRISPR-cas promoters, permits only weak transcription of the crRNA precursor; its role is antagonized by LeuO. Subject to transcriptional auto-repression. Binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Directproteinsequencing; DNA-binding; Referenceproteome; Repressor; Transcription; Transcriptionregulation
Protein Sequence
 MSEALKILNN IRTLRAQARE CTLETLEEML EKLEVVVNER REEESAAAAE VEERTRKLQQ 60
 YREMLIADGI DPNELLNSLA AVKSGTKAKR AQRPAKYSYV DENGETKTWT GQGRTPAVIK 120
 KAMDEQGKSL DDFLIKQ 137
  GO:0005622   C:intracellular IEA:InterPro
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0003681   F:bent DNA binding IDA:EcoliWiki
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR027444   H-NS_C_dom.
  IPR001801   Histone_HNS.
  IPR027454   Histone_HNS_oligo_dom.
  PF00816   Histone_HNS.
  SM00528   HNS.