UniProt Accession

 HINT_ECOLI;  P0ACE7;  P36950;  P75945

Genbank Protein ID

 U00096;  AP009048;  X17615

Genbank Nucleotide ID

 AAC74187.1;  BAA35910.1

Protein Name

 HIT-like protein HinT

Protein Synonyms/Alias

 

Gene Name

 hinT

Gene Synonyms/Alias

 ycfF; OrderedLocusNames=b1103, JW1089

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]

Functional Description From UniProt

 FUNCTION: Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N- epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Required for growth at high salt concentrations Required for normal DadA activity and the ability to grow with D,L-alanine as carbon source

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Completeproteome; Hydrolase; Nucleotide-binding; Referenceproteome

Protein Sequence

  GO:0043530   F:adenosine 5'-monophosphoramidase activity IDA:EcoCyc
  GO:0000166   F:nucleotide binding IEA:UniProtKB-KW
  GO:0055130   P:D-alanine catabolic process IMP:EcoCyc

  IPR019808   Histidine_triad_CS.
  IPR001310   Histidine_triad_HIT.
  IPR011146   HIT-like.

  PF01230   HIT.

  PS00892   HIT_1.
  PS51084   HIT_2.

  PR00332   HISTRIAD.